3-[Bis(trimethylsilyl)amino]-2-methylpropanoic acid trimethylsilyl ester

Base Information

• Chemical Name: 3-[Bis(trimethylsilyl)amino]-2-methylpropanoic acid trimethylsilyl ester
• CAS No.: 55125-15-0
• Molecular Formula: C13H33NO2Si3
• Molecular Weight: 319.667
• Hs Code.: 2931900090
• Mol file: 55125-15-0.mol

Synonyms:Propanoic acid,3-[bis(trimethylsilyl)amino]-2-methyl-,trimethylsilyl ester;

Chemical Property of 3-[Bis(trimethylsilyl)amino]-2-methylpropanoic acid trimethylsilyl ester

Chemical Property:

• PSA: 29.54000
• LogP: 3.97240

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-[Bis(trimethylsilyl)amino]-2-methylpropanoic acid trimethylsilyl ester

There total 3 articles about 3-[Bis(trimethylsilyl)amino]-2-methylpropanoic acid trimethylsilyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

1,1-bis(trimethylsilyloxy)prop-1-ene (31469-22-4) + N-(methoxymethyl)-1,1,1-trimethyl-N-(trimethylsilyl)silanamine (88211-44-3) → N,N,O-Tris-(trimethylsilyl)-β-aminoisobuttersaeure (55125-15-0)

Guidance literature:

trimethylsilyl trifluoromethanesulfonate; In dichloromethane; at 25 - 30 ℃; for 1h;

Reference yield:

1,1,1,3,3,3-hexamethyl-disilazane (999-97-3) → N,N,O-Tris-(trimethylsilyl)-β-aminoisobuttersaeure (55125-15-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 86 percent / n-BuLi / tetrahydrofuran; hexane / 2 h / 0 °C

2: 81 percent / trimethylsilyl trifluoromethanesulfonate / CH₂Cl₂ / 1 h / 25 - 30 °C

With n-butyllithium; trimethylsilyl trifluoromethanesulfonate; In tetrahydrofuran; hexane; dichloromethane;

Reference yield:

→ N,N,O-Tris-(trimethylsilyl)-β-aminoisobuttersaeure (55125-15-0)

Guidance literature:

β-Amino-isobuttersaeure, Bis-TMS-trifluoracetamid;

DOI:10.1016/S0021-9673(00)93539-8

upstream raw materials:

1,1-bis(trimethylsilyloxy)prop-1-ene

N-(methoxymethyl)-1,1,1-trimethyl-N-(trimethylsilyl)silanamine

1,1,1,3,3,3-hexamethyl-disilazane

Downstream raw materials:

DL-3-aminoisobutyric acid