2-(p-Hydroxyphenyl)-2-phenyl-acetophenone

Base Information

• Chemical Name: 2-(p-Hydroxyphenyl)-2-phenyl-acetophenone
• CAS No.: 5543-98-6
• Molecular Formula: C20H16O2
• Molecular Weight: 288.346
• DSSTox Substance ID: DTXSID80522215
• Mol file: 5543-98-6.mol

Synonyms:5543-98-6;2-(p-Hydroxyphenyl)-2-phenyl-acetophenone;2-(4-HYDROXYPHENYL)-1,2-DIPHENYLETHANONE;2-(4-Hydroxyphenyl)-1,2-diphenyl-ethanone;p-Desylphenol;2-(4-Hydroxyphenyl)-1,2-diphenylethan-1-one;SCHEMBL16807278;DTXSID80522215

Chemical Property of 2-(p-Hydroxyphenyl)-2-phenyl-acetophenone

Chemical Property:

• PSA: 37.30000
• LogP: 4.40700
• Solubility.: Chloroform, Methanol
• XLogP3: 4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• Exact Mass: 288.115029749
• Heavy Atom Count: 22
• Complexity: 345

Purity/Quality:

98.5% ^*data from raw suppliers

2-(p-Hydroxyphenyl)-2-phenyl-acetophenone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C(C2=CC=C(C=C2)O)C(=O)C3=CC=CC=C3
• Uses: Photoinitiator in the curing of hexanediol diacrylate. Intermediate in the preparation of clomiphene and tamoxifen analogs.

Technology Process of 2-(p-Hydroxyphenyl)-2-phenyl-acetophenone

There total 7 articles about 2-(p-Hydroxyphenyl)-2-phenyl-acetophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

phenyl benzyl ketone (451-40-1) + p-Iodophenol (540-38-5) → 2-(4-hydroxyphenyl)-1,2-diphenyl-ethan-1-one (5543-98-6)

Guidance literature:

With copper(l) iodide; 2-acetylcyclohexanone; caesium carbonate; In tert-butyl alcohol; at 70 ℃; for 24h; Inert atmosphere;

DOI:10.1002/anie.201206024

Reference yield: 77.5%

2-(4-methoxyphenyl)-1,2-diphenylethan-1-one (5543-97-5) → 2-(4-hydroxyphenyl)-1,2-diphenyl-ethan-1-one (5543-98-6)

Guidance literature:

With hydrogen bromide; In acetic acid; for 6h; Heating;

DOI:10.1002/jps.2600820911

Reference yield:

2-hydroxy-2-phenylacetophenone (119-53-9,579-44-2) → 2-(4-hydroxyphenyl)-1,2-diphenyl-ethan-1-one (5543-98-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 81 percent / 89percent phosphoric acid / 8 h / 135 - 140 °C

2: 77.5 percent / 48percent hydrobromic acid / acetic acid / 6 h / Heating

With phosphoric acid; hydrogen bromide; In acetic acid;

DOI:10.1002/jps.2600820911

upstream raw materials:

2-hydroxy-2-phenylacetophenone

phenol

2-phenoxy-1,2-diphenylethanone

2-(4-methoxyphenyl)-1,2-diphenylethan-1-one

Downstream raw materials:

2-(4-β-chloroethoxyphenyl)-1,2-diphenyl-ethan-1-one

p-benzylphenol

benzoic acid

1,1'-(1,2-ethanediyl)bisbenzene