2-[(2,3-Dihydro-benzo[1,4]dioxin-2-ylmethyl)-methyl-amino]-ethanol

Base Information

Chemical Name:2-[(2,3-Dihydro-benzo[1,4]dioxin-2-ylmethyl)-methyl-amino]-ethanol
CAS No.:73120-83-9
Molecular Formula:C₁₂H₁₇NO₃
Molecular Weight:223.272
Hs Code.:
NSC Number:106900
Nikkaji Number:J92.926C

Synonyms:73120-83-9;2-[(2,3-Dihydro-benzo[1,4]dioxin-2-ylmethyl)-methyl-amino]-ethanol;2-(((2,3-Dihydrobenzo[b][1,4]dioxin-2-yl)methyl)(methyl)amino)ethanol;NSC 106900;BRN 0206249;2-[2,3-dihydro-1,4-benzodioxin-3-ylmethyl(methyl)amino]ethanol;2-[(2,3-dihydro-1,4-benzodioxin-2-ylmethyl)(methyl)amino]ethanol;NSC106900;2-(N-Methyl-N-(2-hydroxyethyl)aminomethyl)-1,4-benzodioxan;Ethanol, 2-(N-(1,4-benzodioxan-2-yl)methyl-N-methyl)amino-;NSC-106900;AM101199;2-[(2,3-Dihydrobenzo[1,4]dioxin-2-ylmethyl)methylamino]ethanol

Suppliers and Price of 2-[(2,3-Dihydro-benzo[1,4]dioxin-2-ylmethyl)-methyl-amino]-ethanol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 6 raw suppliers

Chemical Property of 2-[(2,3-Dihydro-benzo[1,4]dioxin-2-ylmethyl)-methyl-amino]-ethanol

Chemical Property:

Vapor Pressure:2.17E-05mmHg at 25°C
Boiling Point:346.5°Cat760mmHg
Flash Point:163.4°C
Density:1.152g/cm³
XLogP3:1.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:223.12084340
Heavy Atom Count:16
Complexity:212

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CN(CCO)CC1COC2=CC=CC=C2O1

Technology Process of 2-[(2,3-Dihydro-benzo[1,4]dioxin-2-ylmethyl)-methyl-amino]-ethanol

There total 5 articles about 2-[(2,3-Dihydro-benzo[1,4]dioxin-2-ylmethyl)-methyl-amino]-ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 2242-31-1
2-(N-methylaminomethyl)-2,3-dihydro-1,4-benzodioxin

: 540-51-2
2-bromoethanol

: 73120-83-9
N-Methyl-N-(2-hydroxyethyl)(2,3-dihydro-1,4-benzodioxin-2-yl)methanamine

Guidance literature:: With triethylamine; In toluene; Heating;
DOI:10.1021/jm00126a042

Reference yield:

: 21398-80-1
N-methyl-2,3-dihydrobenzo[b][1,4]dioxine-2-carboxamide

: 73120-83-9
N-Methyl-N-(2-hydroxyethyl)(2,3-dihydro-1,4-benzodioxin-2-yl)methanamine

Guidance literature:: Multi-step reaction with 2 steps

1: LiAlH₄ / tetrahydrofuran / 24 h / 50 °C

2: 50 percent / K₂CO₃ / dimethylformamide / 48 h / 80 °C

With lithium aluminium tetrahydride; potassium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide; 1: Reduction / 2: Alkylation;
DOI:10.1016/S0223-5234(00)00164-1

Reference yield:

: 4739-94-0
ethyl 2,3-dihydro-1,4-benzodioxin-2-carboxylate

: 73120-83-9
N-Methyl-N-(2-hydroxyethyl)(2,3-dihydro-1,4-benzodioxin-2-yl)methanamine

Guidance literature:: Multi-step reaction with 3 steps

1: 75 percent / toluene; H₂O / 40 h / 35 °C

2: LiAlH₄ / tetrahydrofuran / 24 h / 50 °C

3: 50 percent / K₂CO₃ / dimethylformamide / 48 h / 80 °C

With lithium aluminium tetrahydride; potassium carbonate; In tetrahydrofuran; water; N,N-dimethyl-formamide; toluene; 1: Substitution / 2: Reduction / 3: Alkylation;
DOI:10.1016/S0223-5234(00)00164-1