1-Chloro-4-[(chloromethoxy)methyl]benzene

Base Information

• Chemical Name: 1-Chloro-4-[(chloromethoxy)methyl]benzene
• CAS No.: 56377-71-0
• Molecular Formula: C8H8Cl2O
• Molecular Weight: 191.057
• DSSTox Substance ID: DTXSID60513606
• Wikidata: Q82373510
• Mol file: 56377-71-0.mol

Synonyms:1-Chloro-4-[(chloromethoxy)methyl]benzene;1197-57-5;56377-71-0;SCHEMBL7219594;4-chlorobenzyl chloromethyl ether;DTXSID60513606;HDJREAPJJPGWHP-UHFFFAOYSA-N;MFCD20621593;AKOS017529169;SY309220

Chemical Property of 1-Chloro-4-[(chloromethoxy)methyl]benzene

Chemical Property:

• XLogP3: 2.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 3
• Exact Mass: 189.9952203
• Heavy Atom Count: 11
• Complexity: 100

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=CC=C1COCCl)Cl

Technology Process of 1-Chloro-4-[(chloromethoxy)methyl]benzene

There total 2 articles about 1-Chloro-4-[(chloromethoxy)methyl]benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

4-chlorobenzaldehyde dimethyl acetal (3395-81-1) → (α,4-Dichlorbenzyl)methylether (56377-71-0)

Guidance literature:

With thionyl chloride; acetyl chloride; at 50 - 60 ℃; for 0.75h;

Reference yield:

4-chlorobenzaldehyde dimethyl acetal (3395-81-1) + acetyl chloride (75-36-5) → (α,4-Dichlorbenzyl)methylether (56377-71-0)

Guidance literature:

With thionyl chloride; at 55 ℃;

Reference yield: 66.0%

1-(1-naphthyl)-1-(2-(1-hydroxyphenyl))methylenimine (41839-61-6) + (α,4-Dichlorbenzyl)methylether (56377-71-0) → 4-Chlor-α-methoxy-N-(1-naphthylphenylmethylen)benzylamin (119208-76-3)

Guidance literature:

With triethylamine; In benzene; for 0.0833333h; Heating;

upstream raw materials:

4-chlorobenzaldehyde dimethyl acetal

acetyl chloride

Downstream raw materials:

methylene chloride

4-chlorobenzaldehyde

4-Chlor-α-methoxy-N-(1-naphthylphenylmethylen)benzylamin

4-Chlor-N-(2,2-dimethyl-1-phenylpropyliden)-α-methoxybenzylamin