Carbamic acid, [(ethoxymethoxyphosphinyl)phenylmethyl]-, phenylmethyl ester

Base Information

• Chemical Name: Carbamic acid, [(ethoxymethoxyphosphinyl)phenylmethyl]-, phenylmethyl ester
• CAS No.: 59191-31-0
• Molecular Formula: C₁₈H₂₂NO₅P
• Molecular Weight: 363.35
• Mol file: 59191-31-0.mol

Synonyms:(Benzyloxycarbonylamino-phenyl-methyl)-phosphonic acid ethyl ester methyl ester;

Chemical Property of Carbamic acid, [(ethoxymethoxyphosphinyl)phenylmethyl]-, phenylmethyl ester

Chemical Property:

• PSA: 83.67000
• LogP: 4.87850

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Carbamic acid, [(ethoxymethoxyphosphinyl)phenylmethyl]-, phenylmethyl ester

There total 5 articles about Carbamic acid, [(ethoxymethoxyphosphinyl)phenylmethyl]-, phenylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

methyl dichlorophosphite (3279-26-3) + ethanol (64-17-5) + O-benzyl carbamate (621-84-1) + benzaldehyde (100-52-7) → methyl 1-(benzyloxycarbonylamino)benzyl phosphonate (58455-89-3,67564-42-5,67564-44-7) + Ethyl methyl (N-benzyloxycarbonylamino)(phenyl)methylphosphonate (59191-31-0)

Guidance literature:

methyl dichlorophosphite; O-benzyl carbamate; benzaldehyde; In benzene; at 20 - 80 ℃; for 7h;

ethanol; With triethylamine; In benzene; Further stages.;

DOI:10.1039/b008340m

Reference yield:

1-amino-1-phenylmethylphosphonic acid (18108-22-0) → Ethyl methyl (N-benzyloxycarbonylamino)(phenyl)methylphosphonate (59191-31-0)

Guidance literature:

Multi-step reaction with 3 steps

2: CCl₃CN

3: diethyl ether

With trichloroacetonitrile; In diethyl ether;

Reference yield:

α-(N-benzyloxycarbonyl)amino-benzylphosphonic acid (53558-70-6) → Ethyl methyl (N-benzyloxycarbonylamino)(phenyl)methylphosphonate (59191-31-0)

Guidance literature:

Multi-step reaction with 2 steps

1: CCl₃CN

2: diethyl ether

With trichloroacetonitrile; In diethyl ether;

upstream raw materials:

diazomethane

ethyl hydrogen α-(benzyloxycarbonylamino)benzylphosphonate

methyl iodide

methyl dichlorophosphite