6-Chloro-9-Ethyl-9H-Purine

Base Information

• Chemical Name: 6-Chloro-9-Ethyl-9H-Purine
• CAS No.: 5462-86-2
• Molecular Formula: C7H7ClN4
• Molecular Weight: 182.612
• Hs Code.: 2933990090
• Mol file: 5462-86-2.mol

Synonyms:6-Chlor-9-aethyl-9H-purin;9-Aethyl-6-chlor-9H-purin;9-ethyl-6-chloropurine;F2124-0079;6-Chlor-9-aethyl-purin;9H-Purine,6-chloro-9-ethyl;6-chloro-9-ethyl-purine;6-chloro-9-ethyl-9H-purine;

Chemical Property of 6-Chloro-9-Ethyl-9H-Purine

Chemical Property:

• Vapor Pressure: 0.000209mmHg at 25°C
• Boiling Point: 326.9°Cat760mmHg
• Flash Point: 151.5°C
• PSA: 43.60000
• Density: 1.5g/cm³
• LogP: 1.49960

Purity/Quality:

99% ^*data from raw suppliers

6-Chloro-9-ethyl-9H-purine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-Chloro-9-Ethyl-9H-Purine

There total 12 articles about 6-Chloro-9-Ethyl-9H-Purine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

diethoxymethyl acetate (14036-06-7) + 6-chloro-N4-ethylpyrimidine-4,5-diamine (98140-03-5) → 6-chloro-9-ethyl-9H-purine (5462-86-2)

Guidance literature:

at 20 ℃; for 48h;

DOI:10.1016/j.bmc.2009.02.030

Reference yield: 68.1%

9-ethyladenine (2715-68-6) → 6-chloro-9-ethyl-9H-purine (5462-86-2)

Guidance literature:

With tetrachloromethane; n-Amyl nitrite; for 12h; Heating;

DOI:10.1021/jo01308a004

Reference yield: 66.0%

ethyl bromide (74-96-4) + 6-chloro-7H-purine (87-42-3,111055-92-6) → 6-chloro-9-ethyl-9H-purine (5462-86-2)

Guidance literature:

6-chloro-7H-purine; With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

ethyl bromide; In N,N-dimethyl-formamide; for 24h;

upstream raw materials:

diethoxymethyl acetate

6-chloro-N⁴-ethylpyrimidine-4,5-diamine

9-ethyladenine

ethyl iodide

Downstream raw materials:

N⁶,N⁶-Dimethyl-9-ethyladenine

9-Ethyl-9H-purin-6(1H)-thion

9-Ethylpurine

Cyclohexyl-(9-ethyl-9H-purin-6-yl)-amine

Refernces

• 1、 Methot, Joey L.,Zhou, Hua,McGowan, Meredeth A.,Anthony, Neville John,Christopher, Matthew,Garcia, Yudith,Achab, Abdelghani,Lipford, Kathryn,Trotter, Benjamin Wesley,Altman, Michael D.,Fradera, Xavier,Lesburg, Charles A.,Li, Chaomin,Alves, Stephen,Chappell, Craig P.,Jain, Renu,Mangado, Ruban,Pinheiro, Elaine,Williams, Sybill M. G.,Goldenblatt, Peter,Hill, Armetta,Shaffer, Lynsey,Chen, Dapeng,Tong, Vincent,McLeod, Robbie L.,Lee, Hyun-Hee,Yu, Hongshi,Shah, Sanjiv,Katz, Jason D.. "Projected Dose Optimization of Amino- And Hydroxypyrrolidine Purine PI3KδImmunomodulators". . p. 5137 - 5156. Retrieved 2021/05/04.
• 2、 Zhou, Dagui,Xie, Dandan,He, Fangcheng,Song, Baoan,Hu, Deyu. "Antiviral properties and interaction of novel chalcone derivatives containing a purine and benzenesulfonamide moiety". . p. 2091 - 2097. Retrieved 2018/05/08.