Methyl 2-(2-hydroxy-1-naphthyl)-2-methoxyacetate

Base Information

• Chemical Name: Methyl 2-(2-hydroxy-1-naphthyl)-2-methoxyacetate
• CAS No.: 624722-15-2
• Molecular Formula: C14H14O4
• Molecular Weight: 246.25900
• Hs Code.: 2918990090
• DSSTox Substance ID: DTXSID10377295
• Nikkaji Number: J1.984.809D
• Mol file: 624722-15-2.mol

Synonyms:624722-15-2;Methyl 2-(2-hydroxy-1-naphthyl)-2-methoxyacetate;methyl 2-(2-hydroxynaphthalen-1-yl)-2-methoxyacetate;DTXSID10377295;MFCD06411620;AKOS005070688;CS-0364397;5Y-0212;Methyl (2-hydroxynaphthalen-1-yl)(methoxy)acetate;J-521815;Methoxy(2-hydroxy-1-naphthyl)acetic acid methyl ester;methyl2-(2-hydroxynaphthalen-1-yl)-2-methoxyacetate

Chemical Property of Methyl 2-(2-hydroxy-1-naphthyl)-2-methoxyacetate

Chemical Property:

• Melting Point: 117-118°C
• PSA: 55.76000
• LogP: 2.40590
• XLogP3: 2.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 4
• Exact Mass: 246.08920892
• Heavy Atom Count: 18
• Complexity: 292

Purity/Quality:

98%min ^*data from raw suppliers

Methyl 2-(2-hydroxy-1-naphthyl)-2-methoxyacetate >95% ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC(C1=C(C=CC2=CC=CC=C21)O)C(=O)OC

Technology Process of Methyl 2-(2-hydroxy-1-naphthyl)-2-methoxyacetate

There total 3 articles about Methyl 2-(2-hydroxy-1-naphthyl)-2-methoxyacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

methanol (67-56-1) + Glyoxilic acid (298-12-4) + β-naphthol (135-19-3) → methyl α-methoxy-α-(2-hydroxy-1-naphthyl)acetate (624722-15-2)

Guidance literature:

With acetamide; toluene-4-sulfonic acid; for 84h; Reflux;

DOI:10.1055/s-0030-1260958

Reference yield:

β-naphthol (135-19-3) → methyl α-methoxy-α-(2-hydroxy-1-naphthyl)acetate (624722-15-2)

Guidance literature:

Multi-step reaction with 2 steps

1: aq. KOH / 4 h / 20 °C

2: H₂SO₄ / 3 h / Heating

With potassium hydroxide; sulfuric acid;

DOI:10.1055/s-2004-815953

Reference yield:

methanol (67-56-1) + α-hydroxy-α-(2-hydroxy-1-naphthyl)acetic acid (624722-10-7,624722-11-8,624722-13-0) → methyl α-methoxy-α-(2-hydroxy-1-naphthyl)acetate (624722-15-2)

Guidance literature:

With sulfuric acid; for 3h; Heating;

DOI:10.1055/s-2004-815953

upstream raw materials:

methanol

α-hydroxy-α-(2-hydroxy-1-naphthyl)acetic acid

β-naphthol

Glyoxilic acid

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