2-hydroxy-2-(2-hydroxynaphthalen-1-yl)acetic Acid

Base Information

• Chemical Name: 2-hydroxy-2-(2-hydroxynaphthalen-1-yl)acetic Acid
• CAS No.: 624722-10-7
• Molecular Formula: C₁₂H₁₀O₄
• Molecular Weight: 218.209
• Hs Code.: 2918199090
• DSSTox Substance ID: DTXSID50377294
• Nikkaji Number: J1.774.487I
• Mol file: 624722-10-7.mol

Synonyms:624722-10-7;2-hydroxy-2-(2-hydroxynaphthalen-1-yl)acetic Acid;2-Hydroxy-2-(2-hydroxy-1-naphthyl)acetic acid;2-Hydroxy-2-(2-hydroxynaphthalen-1-yl)aceticacid;SCHEMBL7210924;DTXSID50377294;ZZA72210;MFCD06411618;AKOS005070678;Hydroxy(2-hydroxynaphth-1-yl)acetic acid;alpha,2-Dihydroxy-1-naphthaleneacetic acid;CS-0322792;5Y-0200;J-509607;2-hydroxy-2-(2-hydroxy-1-naphthyl)acetic acid, AldrichCPR

Chemical Property of 2-hydroxy-2-(2-hydroxynaphthalen-1-yl)acetic Acid

Chemical Property:

• Melting Point: 129～130℃
• PSA: 77.76000
• LogP: 1.66340
• XLogP3: 2.3
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 218.05790880
• Heavy Atom Count: 16
• Complexity: 266

Purity/Quality:

98%Min ^*data from raw suppliers

2-hydroxy-2-(2-hydroxy-1-naphthyl)aceticAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C2C(=C1)C=CC(=C2C(C(=O)O)O)O

Technology Process of 2-hydroxy-2-(2-hydroxynaphthalen-1-yl)acetic Acid

There total 2 articles about 2-hydroxy-2-(2-hydroxynaphthalen-1-yl)acetic Acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

glyoxylic acid ethyl ester (924-44-7) + β-naphthol (135-19-3) → α-hydroxy-α-(2-hydroxy-1-naphthyl)acetic acid (624722-10-7,624722-11-8,624722-13-0)

Guidance literature:

With titanium tetrachloride; In dichloromethane; toluene; at 0 ℃; for 0.75h; Inert atmosphere;

Reference yield:

Glyoxilic acid (298-12-4) + β-naphthol (135-19-3) → α-hydroxy-α-(2-hydroxy-1-naphthyl)acetic acid (624722-10-7,624722-11-8,624722-13-0)

Guidance literature:

With potassium hydroxide; at 20 ℃; for 4h;

DOI:10.1055/s-2004-815953

Reference yield:

methanol (67-56-1) + α-hydroxy-α-(2-hydroxy-1-naphthyl)acetic acid (624722-10-7,624722-11-8,624722-13-0) → methyl α-methoxy-α-(2-hydroxy-1-naphthyl)acetate (624722-15-2)

Guidance literature:

With sulfuric acid; for 3h; Heating;

DOI:10.1055/s-2004-815953

upstream raw materials:

Glyoxilic acid

β-naphthol

glyoxylic acid ethyl ester

Downstream raw materials:

methyl α-methoxy-α-(2-hydroxy-1-naphthyl)acetate

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