Benzenebutanoic acid, 4-Methoxy-g-oxo-, Methyl ester

Base Information

• Chemical Name: Benzenebutanoic acid, 4-Methoxy-g-oxo-, Methyl ester
• CAS No.: 5447-74-5
• Molecular Formula: C12H14O4
• Molecular Weight: 222.241
• Mol file: 5447-74-5.mol

Synonyms:

Chemical Property of Benzenebutanoic acid, 4-Methoxy-g-oxo-, Methyl ester

Chemical Property:

• Vapor Pressure: 4.03E-05mmHg at 25°C
• Melting Point: 46 - 49°C
• Boiling Point: 351.7°Cat760mmHg
• Flash Point: 155.6°C
• PSA: 52.60000
• Density: 1.122g/cm³
• LogP: 1.83110
• Storage Temp.: Refrigerator, under inert atmosphere
• Solubility.: Chloroform (Slightly), Methanol (Slightly)

Purity/Quality:

99%min ^*data from raw suppliers

Methyl4-(4-methoxyphenyl)-4-oxobutyrate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzenebutanoic acid, 4-Methoxy-g-oxo-, Methyl ester

There total 36 articles about Benzenebutanoic acid, 4-Methoxy-g-oxo-, Methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

methanol (67-56-1) + 4-(4-methoxy-phenyl)-4-oxo-butyric acid (3153-44-4) → methyl 3-(4-methoxybenzoyl)propionate (5447-74-5)

Guidance literature:

With sulfuric acid; at 68 ℃;

DOI:10.1002/adsc.201701304

Reference yield: 98.0%

4-methoxyphenyl magnesium bromide (13139-86-1) + succinic acid monomethylester chloride (1490-25-1) → methyl 3-(4-methoxybenzoyl)propionate (5447-74-5)

Guidance literature:

With copper(I) bromide; lithium bromide; In tetrahydrofuran; at 20 ℃;

DOI:10.1016/j.tetlet.2008.08.102

Reference yield: 96.0%

C12H14O4 → methyl 3-(4-methoxybenzoyl)propionate (5447-74-5)

Guidance literature:

With N,N,N,N,-tetramethylethylenediamine; magnesium methanolate; In methanol; at 20 ℃; for 2h;

DOI:10.1039/c7ob00131b

upstream raw materials:

methyl hydrogen succinate

methoxybenzene

methanol

4-(4-methoxy-phenyl)-4-oxo-butyric acid

Downstream raw materials:

Methyl (+/-)-γ-hydroxy-γ-(p-methoxyphenyl)butyrate

Methyl 3-bromo-4-keto-4-(4'-methoxyphenyl)butanoate

(R)-1-(4’-methoxyphenyl)butan-1,4-diol

(S)-1-(4’-methoxyphenyl)butan-1,4-diol

Refernces

• 1、 Khan, Imran,Luo, Zhibin,Xu, Yin,Xie, Jimin,Zhu, Weihua,Liu, Bin. "Transition Metal-Free Alkyne-Aldehyde Reductive C?C Coupling trough Cascade Borylation/Olefin Isomerization". . . Retrieved 2020/05/04.
• 2、 Seo, Jeong Moo,Hassan, Ahmed H.E.,Lee, Yong Sup. "An expeditious entry to rare tetrahydroimidazo[1,5-c]pyrrolo[1,2-a]pyrimidin-7(8H)-ones: A single-step gateway synthesis of glochidine congeners". supporting information. . Retrieved 2019/11/26.