1-Methoxy-3-phenoxypropan-2-one

Base Information

• Chemical Name: 1-Methoxy-3-phenoxypropan-2-one
• CAS No.: 63240-49-3
• Molecular Formula: C10H12O3
• Molecular Weight: 180.203
• DSSTox Substance ID: DTXSID60565549
• Nikkaji Number: J2.568.555E
• Wikidata: Q82450702
• Mol file: 63240-49-3.mol

Synonyms:1-Methoxy-3-phenoxypropan-2-one;63240-49-3;SCHEMBL15493961;DTXSID60565549;AKOS018122743

Chemical Property of 1-Methoxy-3-phenoxypropan-2-one

Chemical Property:

• XLogP3: 0.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 5
• Exact Mass: 180.078644241
• Heavy Atom Count: 13
• Complexity: 150

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COCC(=O)COC1=CC=CC=C1

Technology Process of 1-Methoxy-3-phenoxypropan-2-one

There total 4 articles about 1-Methoxy-3-phenoxypropan-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

N‐methoxy‐N‐methyl‐2‐phenoxyacetamide (91012-53-2) + chloromethyl methyl ether (107-30-2) → 1-methoxy-3-phenoxypropane-2-one (63240-49-3)

Guidance literature:

With 4,4'-di-tert-butylbiphenyl; lithium; In tetrahydrofuran; mineral oil; at -78 ℃; for 3.5h; Inert atmosphere; Schlenk technique;

DOI:10.1039/c6cc03532a

Reference yield: 85.0%

methanol (67-56-1) + Phenyl glycidyl ether (122-60-1,71031-02-2) → 1-methoxy-3-phenoxypropane-2-one (63240-49-3)

Guidance literature:

With potassium peroxomonosulfate; molybdenum(VI) dichloride dioxide; for 2h; Heating;

DOI:10.1055/s-2008-1032163

Reference yield: 40.7%

1-methoxy-3-phenoxy-propan-2-ol (32017-84-8) → 1-methoxy-3-phenoxypropane-2-one (63240-49-3)

Guidance literature:

1-methoxy-3-phenoxy-propan-2-ol; With oxalyl dichloride; dimethyl sulfoxide; In dichloromethane; at -78 ℃; for 0.25h; Inert atmosphere;

With triethylamine; In dichloromethane; at -78 - 20 ℃; for 0.5h; Inert atmosphere;

DOI:10.1021/acs.orglett.7b00756

upstream raw materials:

1-methoxy-3-phenoxy-propan-2-ol

methanol

Phenyl glycidyl ether

N‐methoxy‐N‐methyl‐2‐phenoxyacetamide