N-methoxy-N-methyl-2-phenoxyacetamide

Base Information

• Chemical Name: N-methoxy-N-methyl-2-phenoxyacetamide
• CAS No.: 91012-53-2
• Molecular Formula: C10H13NO3
• Molecular Weight: 195.218
• Hs Code.: 2924299090
• DSSTox Substance ID: DTXSID70920009
• Nikkaji Number: J86.324F
• Wikidata: Q82892654
• Mol file: 91012-53-2.mol

Synonyms:N-methoxy-N-methyl-2-phenoxyacetamide;91012-53-2;BRN 2452057;(N-METHOXY-N-METHYLCARBAMOYLMETHYL)PHENOXYMETHANE;N-Methoxy-N-methyl phenoxyacetamide;MFCD01672936;N,O-Dimethyl-2-phenoxyacetohydroxamic acid;ACETOHYDROXAMIC ACID, N,O-DIMETHYL-2-PHENOXY-;n-methoxy-n-methyl-2-phenoxy-acetamide;SCHEMBL4842036;DTXSID70920009;AKOS008953008;FT-0695187;F1903-0149

Chemical Property of N-methoxy-N-methyl-2-phenoxyacetamide

Chemical Property:

• Vapor Pressure: 0.00466mmHg at 25°C
• Boiling Point: 277°Cat760mmHg
• Flash Point: 121.3°C
• PSA: 38.77000
• Density: 1.123g/cm³
• LogP: 1.08520
• XLogP3: 0.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 195.08954328
• Heavy Atom Count: 14
• Complexity: 178

Purity/Quality:

97% ^*data from raw suppliers

(N-METHOXY-N-METHYLCARBAMOYLMETHYL)PHENOXYMETHANE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CN(C(=O)COC1=CC=CC=C1)OC

Technology Process of N-methoxy-N-methyl-2-phenoxyacetamide

There total 7 articles about N-methoxy-N-methyl-2-phenoxyacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

N,O-dimethylhydroxylamine*hydrochloride (6638-79-5) + 2-phenoxyacetic acid (122-59-8) → N‐methoxy‐N‐methyl‐2‐phenoxyacetamide (91012-53-2)

Guidance literature:

2-phenoxyacetic acid; With 1,1'-carbonyldiimidazole; In dichloromethane; water; at 0 - 20 ℃; for 0.5h; Inert atmosphere;

N,O-dimethylhydroxylamine*hydrochloride; With triethylamine; In dichloromethane; water; at 0 - 20 ℃; Inert atmosphere;

Reference yield: 79.0%

N,O-dimethylhydroxylamine*hydrochloride (6638-79-5) + Phenoxyacetyl chloride (701-99-5) → N‐methoxy‐N‐methyl‐2‐phenoxyacetamide (91012-53-2)

Guidance literature:

With pyridine; In chloroform; for 2h; Ambient temperature;

DOI:10.1246/bcsj.68.350

Reference yield:

phenol (108-95-2,27073-41-2) → N‐methoxy‐N‐methyl‐2‐phenoxyacetamide (91012-53-2)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate / acetone

2: sodium hydroxide; water / ethanol

3: dmap; 4-methyl-morpholine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane

With 4-methyl-morpholine; dmap; water; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In ethanol; dichloromethane; acetone;

upstream raw materials:

N,O-dimethylhydroxylamine*hydrochloride

Phenoxyacetyl chloride

N,0-dimethylhydroxylamine

2-phenoxyacetic acid

Downstream raw materials:

t-butyl-3,5-dioxo-6-phenoxyhexanoate

C₁₂H₁₅ClO₂

1-(4-chloro-pyridin-3-yl)-2-phenoxy-ethanone

1-(2-fluoro-pyridin-3-yl)-2-phenoxy-ethanone