2-Ethoxy-5-methylaniline

Base Information

• Chemical Name: 2-Ethoxy-5-methylaniline
• CAS No.: 6331-70-0
• Molecular Formula: C9H13 N O
• Molecular Weight: 151.208
• Hs Code.: 2922299090
• European Community (EC) Number: 228-708-7
• NSC Number: 37005
• DSSTox Substance ID: DTXSID50979419
• Nikkaji Number: J13.616F
• Wikidata: Q82965053
• Mol file: 6331-70-0.mol

Synonyms:2-Ethoxy-5-methylaniline;6331-70-0;Benzenamine, 2-ethoxy-5-methyl-;o-Phenetidine, 5-methyl-;EINECS 228-708-7;NSC37005;6-Ethoxy-m-toluidine;SCHEMBL1188721;AMY4701;DTXSID50979419;MFCD00035775;NSC 37005;NSC-37005;STL387537;AKOS005264114;DS-12028;BB 0241849;CS-0151510;FT-0757979;I11406;EN300-1232870;A834326

Chemical Property of 2-Ethoxy-5-methylaniline

Chemical Property:

• Vapor Pressure: 0.0193mmHg at 25°C
• Boiling Point: 252.5°C at 760 mmHg
• Flash Point: 109.2°C
• PSA: 35.25000
• Density: 1.018g/cm³
• LogP: 2.55710
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• XLogP3: 2.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 151.099714038
• Heavy Atom Count: 11
• Complexity: 116

Purity/Quality:

97% ^*data from raw suppliers

2-Ethoxy-5-methylaniline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC1=C(C=C(C=C1)C)N

Technology Process of 2-Ethoxy-5-methylaniline

There total 4 articles about 2-Ethoxy-5-methylaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1-ethoxy-4-methyl-2-nitrobenzene (85653-54-9) → 2-ethoxy-5-methylaniline (6331-70-0)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In tetrahydrofuran; at 20 ℃; for 25.5h;

Reference yield:

(2-ethoxy-5-methyl-phenyl)-p-tolyl-diazene (116557-65-4) → 2-ethoxy-5-methylaniline (6331-70-0)

Guidance literature:

With hydrochloride of tin dichloride;

Reference yield:

hydrogenchloride (7647-01-0,15364-23-5) + ethanol (64-17-5) + (2-ethoxy-5-methyl-phenyl)-p-tolyl-diazene (116557-65-4) → 2-ethoxy-5-methylaniline (6331-70-0) + 2-ethoxy-5-methyl-N4-p-tolyl-p-phenylenediamine + 5'-ethoxy-5,2'-dimethyl-biphenyl-2,4'-diyldiamine + p-toluidine (106-49-0,12221-03-3)

Guidance literature:

upstream raw materials:

1-ethoxy-4-methyl-2-nitrobenzene

(2-ethoxy-5-methyl-phenyl)-p-tolyl-diazene

hydrogenchloride

ethanol

Downstream raw materials:

2-ethoxy-5-methylphenol

5-Methyl-2-aethoxy-thiophenol

C₂₂H₃₁N₃O₃