Benzenepropanoic acid, b-hydroxy-b-methyl-a-[(4-methylphenyl)sulfinyl]-, 1,1-dimethylethyl ester

Base Information

Chemical Name:Benzenepropanoic acid, b-hydroxy-b-methyl-a-[(4-methylphenyl)sulfinyl]-, 1,1-dimethylethyl ester
CAS No.:63741-24-2
Molecular Formula:C₂₁H₂₆O₄S
Molecular Weight:374.501
Hs Code.:

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Benzenepropanoic acid, b-hydroxy-b-methyl-a-[(4-methylphenyl)sulfinyl]-, 1,1-dimethylethyl ester

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Technology Process of Benzenepropanoic acid, b-hydroxy-b-methyl-a-[(4-methylphenyl)sulfinyl]-, 1,1-dimethylethyl ester

There total 5 articles about Benzenepropanoic acid, b-hydroxy-b-methyl-a-[(4-methylphenyl)sulfinyl]-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 58059-08-8
tert-butyl (R)-p-toluenesulfinylacetate

: 98-86-2
acetophenone

: 63741-24-2
α-(p-tolylsulfinyl) β-hydroxy β-phenyl n-butanoate de t-butyle

Guidance literature:: With tert-butylmagnesium bromide; In tetrahydrofuran; at -78 ℃; Yield given;
DOI:10.1016/0040-4020(80)80010-X

Reference yield:

: 540-88-5
acetic acid tert-butyl ester

: 63741-24-2
α-(p-tolylsulfinyl) β-hydroxy β-phenyl n-butanoate de t-butyle

Guidance literature:: Multi-step reaction with 2 steps

1: 1) (iPr)2NMgBr; 2) NH₄Cl / 1) THF, ether, -40 to -35 deg C

2: t-BuMgBr / tetrahydrofuran / -78 °C

With bromomagnesium diisopropylamide; tert-butylmagnesium bromide; ammonium chloride; In tetrahydrofuran;
DOI:10.1016/0040-4020(80)80010-X

Reference yield:

: 824-79-3
sodium 4-methylbenzenesulfinate

: 63741-24-2
α-(p-tolylsulfinyl) β-hydroxy β-phenyl n-butanoate de t-butyle

Guidance literature:: Multi-step reaction with 3 steps

1: 1) thyonyl chloride / 1) 1 h, 0 deg C; 2) ether, pyridine, 2 h, RT

2: 1) (iPr)2NMgBr; 2) NH₄Cl / 1) THF, ether, -40 to -35 deg C

3: t-BuMgBr / tetrahydrofuran / -78 °C

With thionyl chloride; bromomagnesium diisopropylamide; tert-butylmagnesium bromide; ammonium chloride; In tetrahydrofuran;
DOI:10.1016/0040-4020(80)80010-X