2-chloro-N-(3-methoxyphenyl)-N-methylacetamide

Base Information

• Chemical Name: 2-chloro-N-(3-methoxyphenyl)-N-methylacetamide
• CAS No.: 65836-81-9
• Molecular Formula: C10H12ClNO2
• Molecular Weight: 213.66100
• Mol file: 65836-81-9.mol

Synonyms:2-Chloro-N-(3-methoxy-phenyl)-N-methyl-acetamide;N-Methyl-N-chloracetyl-m-anisidin;

Chemical Property of 2-chloro-N-(3-methoxyphenyl)-N-methylacetamide

Chemical Property:

• PSA: 29.54000
• LogP: 1.89680

Purity/Quality:

95% ^*data from raw suppliers

2-chloro-N-(3-methoxyphenyl)-N-methylacetamide 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-chloro-N-(3-methoxyphenyl)-N-methylacetamide

There total 2 articles about 2-chloro-N-(3-methoxyphenyl)-N-methylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

3-methoxy-N-methylaniline (14318-66-2) + chloroacetyl chloride (79-04-9) → N-chloroacetyl-N-methyl-m-anisidine (65836-81-9)

Guidance literature:

With sodium hydrogencarbonate; In dichloromethane; water; Ambient temperature;

DOI:10.1248/cpb.29.128

Reference yield:

m-methoxyacetanilide (588-16-9) → N-chloroacetyl-N-methyl-m-anisidine (65836-81-9)

Guidance literature:

Multi-step reaction with 2 steps

1: (i) NaH, xylene, (ii) /BRN= 635994/, (iii) aq. H₂SO₄

2: benzene

In benzene;

DOI:10.1016/S0040-4020(01)96342-2

Reference yield: 66.0%

N-chloroacetyl-N-methyl-m-anisidine (65836-81-9) → 6-methoxy-1-methylindolin-2-one (7703-91-5) + 4-methoxy-1-methyloxindole (7699-21-0)

Guidance literature:

With sodium hydrogencarbonate; In water; acetonitrile; Irradiation;

DOI:10.1248/cpb.29.128

upstream raw materials:

3-methoxy-N-methylaniline

chloroacetyl chloride

m-methoxyacetanilide

Downstream raw materials:

6-methoxy-1-methylindolin-2-one

4-methoxy-1-methyloxindole

Refernces