3-(4-phenylpiperazin-1-yl)propan-1-ol

Base Information

• Chemical Name: 3-(4-phenylpiperazin-1-yl)propan-1-ol
• CAS No.: 67514-07-2
• Molecular Formula: C13H20 N2 O
• Molecular Weight: 220.315
• Mol file: 67514-07-2.mol

Synonyms:1-(3-Hydroxypropyl)-4-phenylpiperazine;NSC 33308

Chemical Property of 3-(4-phenylpiperazin-1-yl)propan-1-ol

Chemical Property:

• Vapor Pressure: 2.74E-06mmHg at 25°C
• Boiling Point: 375°Cat760mmHg
• Flash Point: 190.4°C
• Density: 1.078g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(4-phenylpiperazin-1-yl)propan-1-ol

There total 5 articles about 3-(4-phenylpiperazin-1-yl)propan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

4-phenyl-1-piperazine (92-54-6) + allyl alcohol (107-18-6) → 1-phenyl-4-(3-hydroxypropyl)piperazine (67514-07-2)

Guidance literature:

With C₁₇H₁₆BrMnN₂O₃S; potassium carbonate; In toluene; at 100 ℃; for 24h; chemoselective reaction; Inert atmosphere;

DOI:10.1021/acscatal.1c01199

Reference yield: 94.0%

1-(2-ethoxycarbonylethyl)-4-phenyl-piperazine (56968-65-1) → 1-phenyl-4-(3-hydroxypropyl)piperazine (67514-07-2)

Guidance literature:

In tetrahydrofuran;

Reference yield:

4-phenyl-1-piperazine (92-54-6) + 1-bromo-3-propanol (627-18-9) → 1-phenyl-4-(3-hydroxypropyl)piperazine (67514-07-2)

Guidance literature:

With triethylamine; In acetone; at 20 ℃; for 24h;

DOI:10.1590/S0103-50532010000100011

upstream raw materials:

4-phenyl-1-piperazine

allyl alcohol

1,3-dibromo-propane

1-(2-ethoxycarbonylethyl)-4-phenyl-piperazine

Downstream raw materials:

1-(3-chloropropyl)-4-phenylpiperazine

4-[3-(4-phenylpiperazin-1-yl)propoxy]benzaldehyde

1-<4-formylphenoxy>-3-1-(N⁴-phenylpiperazinyl)>propane

2-{4-[3-(4-Phenyl-piperazin-1-yl)-propoxy]-phenyl}-thiazolidine-3-carbothioic acid methylamide

Refernces

• 1、 Duarte de Almeida, Leandro,Bourriquen, Florian,Junge, Kathrin,Beller, Matthias. "Catalytic Formal Hydroamination of Allylic Alcohols Using Manganese PNP-Pincer Complexes". . p. 4177 - 4181. Retrieved 2021/03/26.
• 2、 Pessoa-Mahana, David,Nu?n?ez, Andre?s,Espinosa, Christian,Mella-Raipa?n, Jaime,Pessoa-Mahana, Herna?n. "Synthesis of a novel series of 4-arylpiperazinyl derivatives linked to a 2-(Pyridin-3-yl)-1H-benzimidazole as new delavirdine analogues". supporting information; experimental part. p. 63 - 70. Retrieved 2010/08/20.