6-(BROMOMETHYL)-1,3-DIMETHYL-2,4-DIOXO-1,2,3,4-TETRAHYDROPYRIMIDINE-5-CARBALDEHYDE

Base Information

• Chemical Name: 6-(BROMOMETHYL)-1,3-DIMETHYL-2,4-DIOXO-1,2,3,4-TETRAHYDROPYRIMIDINE-5-CARBALDEHYDE
• CAS No.: 67220-04-6
• Molecular Formula: C8H9BrN2O3
• Molecular Weight: 261.075
• Mol file: 67220-04-6.mol

Synonyms:6-Brommethyl-1,3-dimethyl-5-formyl-uracil;6-bromomethyl-5-formyl-1,3-dimethyluracyl;6-bromomethyl-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidine-5-carbaldehyde;

Chemical Property of 6-(BROMOMETHYL)-1,3-DIMETHYL-2,4-DIOXO-1,2,3,4-TETRAHYDROPYRIMIDINE-5-CARBALDEHYDE

Chemical Property:

• Melting Point: 129 - 130 °C (H2O)
• Boiling Point: 331.2±52.0 °C(Predicted)
• PKA: -3.69±0.60(Predicted)
• PSA: 61.07000
• Density: 1.721±0.06 g/cm3(Predicted)
• LogP: -0.20860

Purity/Quality:

98%min ^*data from raw suppliers

6-(BROMOMETHYL)-1,3-DIMETHYL-2,4-DIOXO-1,2,3,4-TETRAHYDROPYRIMIDINE-5-CARBALDEHYDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 6-(BROMOMETHYL)-1,3-DIMETHYL-2,4-DIOXO-1,2,3,4-TETRAHYDROPYRIMIDINE-5-CARBALDEHYDE

There total 2 articles about 6-(BROMOMETHYL)-1,3-DIMETHYL-2,4-DIOXO-1,2,3,4-TETRAHYDROPYRIMIDINE-5-CARBALDEHYDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

5-formy-1,3,6-trimethyluracil (23941-84-6) → 5-formyl-1,3-dimethyl-6-bromomethyl-2,4-(1H,3H)-pyrimidinedione (67220-04-6)

Guidance literature:

With bromine; In chloroform; at 50 ℃;

DOI:10.1248/cpb.29.1525

Reference yield:

→ 5-formyl-1,3-dimethyl-6-bromomethyl-2,4-(1H,3H)-pyrimidinedione (67220-04-6)

Guidance literature:

/BRN= 745402/, Brom;

Reference yield: 92.0%

methanol (67-56-1) + 2-amino-benzenethiol (137-07-5) + 5-formyl-1,3-dimethyl-6-bromomethyl-2,4-(1H,3H)-pyrimidinedione (67220-04-6) → 6-(2-aminophenylthio)methyl-1,3-dimethyluracil-5-carboxaldehyde dimethyl acetal (79558-68-2)

Guidance literature:

With triethylamine; for 2h; Ambient temperature;

DOI:10.1248/cpb.29.1525

upstream raw materials:

5-formy-1,3,6-trimethyluracil

Downstream raw materials:

1,3-dimethyl-6-p-tolyl-1,6-dihydro-pyrrolo[3,4-d]pyrimidine-2,4-dione

1,3-dimethyl-6-phenylthiomethyl-5-carboxaldehyde dimethyl acetal

6-(3,4-dimethyl-phenyl)-1,3-dimethyl-1,6-dihydro-pyrrolo[3,4-d]pyrimidine-2,4-dione

1,3-dimethyl-6-phenyl-6H-pyrrolo<3,4-d>pyrimidine-2,4-(1H,3H)-dione

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