3-CHLORO-6-ETHOXYPYRIDAZINE

Base Information

• Chemical Name: 3-CHLORO-6-ETHOXYPYRIDAZINE
• CAS No.: 17321-20-9
• Molecular Formula: C6H7 Cl N2 O
• Molecular Weight: 158.587
• Hs Code.: 2933990090
• Mol file: 17321-20-9.mol

Synonyms:3-Chloro-6-ethoxypyridazine;NSC 94042

Chemical Property of 3-CHLORO-6-ETHOXYPYRIDAZINE

Chemical Property:

• Vapor Pressure: 0.00308mmHg at 25°C
• Melting Point: 60-62℃
• Boiling Point: 293.1°Cat760mmHg
• PKA: 0.82±0.10(Predicted)
• Flash Point: 131.1°C
• PSA: 35.01000
• Density: 1.235g/cm³
• LogP: 1.52870
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

3-Chloro-6-ethoxypyridazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-CHLORO-6-ETHOXYPYRIDAZINE

There total 3 articles about 3-CHLORO-6-ETHOXYPYRIDAZINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

3,6-dichlorpyridazine (141-30-0) + ethanol (64-17-5) → 3-chloro-6-(ethyloxy)pyridazine (17321-20-9)

Guidance literature:

With potassium carbonate; for 22h; Reflux;

DOI:10.1016/j.tet.2015.05.056

Reference yield: 94.0%

3,6-dichlorpyridazine (141-30-0) + sodium ethanolate (141-52-6) → 3-chloro-6-(ethyloxy)pyridazine (17321-20-9)

Guidance literature:

In ethanol; at 20 ℃; for 3.5h;

DOI:10.1021/jm040063i

Reference yield:

→ 3-chloro-6-(ethyloxy)pyridazine (17321-20-9)

Guidance literature:

3,6-Dichlor-pyridazin, Na-O-C2H5 (aus Na und A.), in Aethanol, Erwaermen;

upstream raw materials:

3,6-dichlorpyridazine

ethanol

sodium ethanolate

Downstream raw materials:

6-chloro-2H-pyridazin-3-one

3-(ethyloxy)pyridazine

1-[6-(ethyloxy)pyrazolo[1,5-b]pyridazin-3-yl]ethanone

Refernces

• 1、 Sengmany, Stéphane,Lebre, Julie,Le Gall, Ewan,Léonel, Eric. "Selective mono-amination of dichlorodiazines". . p. 4859 - 4867. Retrieved 2015/08/03.
• 2、 Al-Awadi, Nouria,Taylor, Roger. "The Mechanism of Thermal Eliminations. Part 18. Relative Rates of Pyrolysis of 2-Ethoxypyrazine, 3-Ethoxypyridazine, 2-and 4-Ethoxypyrimidine, 3-Chloro-6-ethoxypyridazine, and 2-Chloro-4-ethoxypyrimidine : the Effect of the Aza 'Substituent' and ?-Bond Order on the Elimination Rate". . p. 1255 - 1258. Retrieved 2007/10/02.