N-(2-methyl-4-oxoquinazolin-3-yl)benzamide

Base Information

• Chemical Name: N-(2-methyl-4-oxoquinazolin-3-yl)benzamide
• CAS No.: 6761-14-4
• Molecular Formula: C16H13N3O2
• Molecular Weight: 279.29300
• DSSTox Substance ID: DTXSID301321458
• ChEMBL ID: CHEMBL1163744
• Mol file: 6761-14-4.mol

Synonyms:6761-14-4;N-(2-methyl-4-oxoquinazolin-3-yl)benzamide;N-(2-Methyl-4-oxo-4H-quinazolin-3-yl)-benzamide;BAS 01023341;Oprea1_089479;Oprea1_613629;MLS001212628;benzamide,n-(2-methyl-4-oxo-3(4h)-quinazolinyl)-;CHEMBL1163744;DTXSID301321458;HMS1680K22;HMS2841I07;STL321727;AKOS000533334;SMR000515837;N-(2-Methyl-4-oxoquinazolin-3(4H)-yl)benzamide;SR-01000316813;SR-01000316813-1;BRD-K42398020-001-07-4

Chemical Property of N-(2-methyl-4-oxoquinazolin-3-yl)benzamide

Chemical Property:

• PSA: 63.99000
• LogP: 2.16180
• XLogP3: 2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 279.100776666
• Heavy Atom Count: 21
• Complexity: 454

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=NC2=CC=CC=C2C(=O)N1NC(=O)C3=CC=CC=C3

Technology Process of N-(2-methyl-4-oxoquinazolin-3-yl)benzamide

There total 8 articles about N-(2-methyl-4-oxoquinazolin-3-yl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

3-amino-2-methyl-4-oxoquinazoline (1898-06-2) + benzoyl chloride (98-88-4) → N-(2-methyl-4-oxoquinazolin-4(3H)-yl)benzamide (6761-14-4)

Guidance literature:

With pyridine; In benzene; for 2h; Heating;

Reference yield: 86.0%

acetic anhydride (108-24-7) + benzoic acid hydrazide (613-94-5) + anthranilic acid (118-92-3,159201-01-1,50816-84-7,80206-34-4,104809-47-4) → N-(2-methyl-4-oxoquinazolin-4(3H)-yl)benzamide (6761-14-4)

Guidance literature:

With titanium dioxide nanoparticles; at 80 ℃; for 9h; Neat (no solvent);

DOI:10.1055/s-0031-1290610

Reference yield: 19.0%

isatoic anhydride (118-48-9) + benzoic acid hydrazide (613-94-5) → 3-amino-2-phenylquinazolin-4(3H)-one (1904-60-5) + N-(2-methyl-4-oxoquinazolin-4(3H)-yl)benzamide (6761-14-4) + N3-acetylamino-2-phenyl-4(3H)-quinazolinone (6761-16-6)

Guidance literature:

With toluene-4-sulfonic acid; In acetic acid; for 9h; Heating;

DOI:10.1055/s-1984-31083

upstream raw materials:

isatoic anhydride

benzoic acid hydrazide

acetic acid

3-amino-2-methyl-4-oxoquinazoline

Downstream raw materials:

4-(o-carboxyphenyl)-3-phenyl-5-methyl(1,2,4) triazole

2-(3-methyl-5-phenyl-[1,2,4]triazol-4-yl)-benzoic acid methyl ester