6761-16-6

Upstream product

• 118-48-9 isatoic anhydride 
• 613-94-5 benzoic acid hydrazide 
• 64-19-7 acetic acid 
• 1904-60-5 3-amino-2-phenylquinazolin-4(3H)-one 
• 108-24-7 acetic anhydride 
• 28864-26-8 acetylhydrazide de l'acide anthranilique 
• 78-39-7 Triethyl orthoacetate 
• 1022-46-4 2-phenyl-4H-3,1-benzoxazin-4-one 
• 98-88-4 benzoyl chloride 
• 118-92-3 anthranilic acid 
• 1904-58-1 anthranilic acid hydrazide 
• 442637-38-9 N-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)-N'-(2-phenyl-4-oxoquinazolin-3-yl)thiourea 
• 30909-95-6 3,4-Dihydro-2-phenyl-5H-1,3,4-benzotriazepin-5-one 

Downstream Products

• 122057-27-6 Cu(C₆H₄NCC₆H₅NCONHCOCH₃)2(CH₃COO)2 
• 122057-27-6 {Cu(II)(2-phenyl-3-acetamino-quinazoline(3H)-4-one)2(acetate)2} 
• 122057-23-2 {Co(II)(2-phenyl-3-acetamino-quinazoline(3H)-4-one)2(acetate)2} 
• 122057-29-8 {Zn(II)(2-phenyl-3-acetamino-quinazoline(3H)-4-one)(acetate)2} 
• 122057-30-1 {Ru(2-phenyl-3-(acetamino) quinazoline-(3H)-4-one)2Cl₂} 
• 122057-30-1 {ruthenium(II)(2-phenyl-3-acetamino-quinazoline-(3H)-4-one)2(Cl)2} 
• 122057-25-4 {Ni(II)(2-phenyl-3-acetamino-quinazoline(3H)-4-one)2(acetate)2} 

Relevant academic research and scientific papers

Synthesis and antiviral evaluation of some new glycosylthioureas containing a quinazolinone nucleus

A new synthesis of glycosylthioureas containing a quinazolinone nucleus is described utilizing per-O-acetylglycopyranosylisothiocyanates and several aminoquinazolinones as starting compounds. Structural proofs of these compounds are provided from elemental analyses, IR, 1H and 13C NMR spectra and mass spectra. The biological activity of these compounds has been studied.

Anti-convulsant potential of quinazolinones

A series of novel quinazoline derivatives were synthesized, virtually screened through different filters and evaluated for their anticonvulsant activity against electrically and chemically induced seizures, compared with that of the standard drugs methaqualone and sodium valproate. Compound 48, 3-(2-aminophenyl)-7-chloro-2-phenylquinazolin-4(3H)-one, was found to be the most potent compound of the series accompanied by relatively low neurotoxicity and low toxicity in the median lethal dose test as compared with the reference drugs. The obtained results showed that compounds 12, 48, 49 and 50 could be useful templates for future design, optimization, and investigation to construct more active analogs.

Identification of novel quinazolin-4(3H)-ones as inhibitors of thermolysin, the prototype of the M4 family of proteinases

A combinatorial series of novel quinazolin-4(3H)-ones were synthesised and their structures were established based on spectroscopic data (IR, NMR, EI-MS, and FAB-MS). The compounds were tested for inhibition of the zinc metalloproteinase thermolysin (TLN) utilizing a chemical array-based approach. Some of the compounds were found to inhibit TLN, with IC50 values ranging from 0.0115 μM (compound 3) to 122,637 μM (compound 29). Compound 3 [3-phenyl-2-(trifluoromethyl) quinazolin-4(3H)-one] (IC50 = 0.0115 μM) and compound 35 [3-(isopropylideneamino)-2,2-dimethyl-2,3-dihydroquinazolin-4 (1H)-one] (IC50 = 0.2477 μM) were found to be the most potent inhibitors.