782-28-5

Usage

Uses

Used in Pharmaceutical Industry:
4-(2-Naphthyl)butanoic acid is used as an intermediate in the synthesis of 4-Phenanthrol (P295015), a metabolite of Phenanthrene. This metabolite has potential applications in the development of pharmaceutical drugs, as it may possess therapeutic properties that can be harnessed for the treatment of various diseases and conditions.
Used in Chemical Synthesis:
In the field of chemical synthesis, 4-(2-Naphthyl)butanoic acid is utilized as a building block for the creation of more complex organic compounds. Its unique structure allows it to be a versatile component in the synthesis of various molecules, making it valuable in research and development efforts.
Used in Research and Development:
4-(2-Naphthyl)butanoic acid is also used in research and development settings to study its properties and explore its potential applications. Scientists and researchers may investigate its reactivity, stability, and interactions with other compounds to better understand its capabilities and identify new uses for this organic compound.

InChI:InChI=1/C14H14O2/c15-14(16)7-3-4-11-8-9-12-5-1-2-6-13(12)10-11/h1-2,5-6,8-10H,3-4,7H2,(H,15,16)

Upstream product

• 6326-90-5 ethyl 4-(naphthalen-2-yl)butanoate 
• 785-19-3 methyl 4-(naphthalen-2-yl)butanoate 
• 2489-87-4 2-allylnaphthalene 
• 32316-92-0 naphthalene-2-boronic acid 
• 180037-65-4 γ-(2-naphthyl)-γ-butyrolactone 
• 625-38-7 but-3-enoic acid 
• 91-20-3 naphthalene 
• 1955-35-7 5-(naphthalen-2-yl)furan-2(3H)-one 
• 785-17-1 4-oxo-4-(5,6,7,8-tetrahydronaphthalen-2-yl)butanoic acid 
• 782-27-4 4-(5,6,7,8-tetrahydronaphthalen-2-yl)butanoic acid 
• 785-18-2 methyl 4-(5,6,7,8-tetrahydronaphthalen-2-yl)butanoate 
• 119-64-2 tetralin 
• 505029-10-7 (2-[2]naphthyl-2-oxo-ethyl)-malonic acid dimethyl ester 
• 50846-93-0 2-chloro-1-(2-naphthyl)ethanone 

Downstream Products

• 610-48-0 1-methylanthracene 
• 25177-45-1 4-Phenanthrylacetic acid 
• 85-01-8 phenanthrene 
• 7651-86-7 4-phenanthrol 
• 178556-70-2 4-(1-Trityl-1H-imidazol-4-yl)-1,2,3,4-tetrahydro-phenanthren-4-ol 
• 2657-44-5 4-(naphthalen-2-yl)butan-1-ol 

Relevant academic research and scientific papers

Preparation method of light-driven molecular motor based on oxidized benzofuran structure

The present invention relates to a preparation method and application of a molecular motor containing oxidized benzofuran structure, belonging to the field of organic chemistry technology. The first motor is based on 3-methyl-2,3-dihydrofyl-4(1H)-ketone and 2-coumarinone as raw materials, the second motor is based on 3-methyl-2,3-dihydrophenanthrene-4(1H)-keto and naphthalene [1,2-b]furan-2(3H)-ketone as raw materials, the third motor with 3-methyl-2,3-dihydrophenanthin-4 (1H)-keto and 6-isopropylphenone-2(3H)-keto as raw materials, in the presence of titanium tetrachloride and 1,8-diazoacyclodo-unicyclic-7-ene, In anhydrous tetrahydrofuran solvents, nucleophilic addition reactions are prepared. The reaction conditions of the present invention are mild, there is no need to add strong acids and strong bases, the equipment requirements are low, the operating cost is reduced; the reaction process produces less waste, the degree of environmental pollution is low; the obtained product motor structure is novel and has potential application value in the field of molecular devices.

Ligand-Controlled Regiodivergence in Nickel-Catalyzed Hydroarylation and Hydroalkenylation of Alkenyl Carboxylic Acids**

A nickel-catalyzed regiodivergent hydroarylation and hydroalkenylation of unactivated alkenyl carboxylic acids is reported, whereby the ligand environment around the metal center dictates the regiochemical outcome. Markovnikov hydrofunctionalization products are obtained under mild ligand-free conditions, with up to 99 % yield and >20:1 selectivity. Alternatively, anti-Markovnikov products can be accessed with a novel 4,4-disubstituted Pyrox ligand in excellent yield and >20:1 selectivity. Both electronic and steric effects on the ligand contribute to the high yield and selectivity. Mechanistic studies suggest a change in the turnover-limiting and selectivity-determining step induced by the optimal ligand. DFT calculations reveal that in the anti-Markovnikov pathway, repulsion between the ligand and the alkyl group is minimized (by virtue of it being 1° versus 2°) in the rate- and regioselectivity-determining transmetalation transition state.

Cationic α-Diimine Nickel and Palladium Complexes Incorporating Phenanthrene Substituents: Highly Active Ethylene Polymerization Catalysts and Mechanistic Studies of syn/ anti Isomerization

α-Diimine palladium complexes incorporating phenanthryl- and 6,7-dimethylphenanthrylimino groups have been synthesized and characterized. The (diimine)PdMeCl complexes prepared from 2,3-butanedione and acenaphthenequinone bearing the unsubstituted phenant

Carbonylative Transformation of Allylarenes with CO Surrogates: Tunable Synthesis of 4-Arylbutanoic Acids, 2-Arylbutanoic Acids, and 4-Arylbutanals

In this Communication, procedures for the selective synthesis of 4-arylbutanoic acids, 2-arylbutanoic acids, and 4-arylbutanals from the same allylbenzenes have been developed. With formic acid or TFBen as the CO surrogate, reactions proceed selectively and effectively under carbon monoxide gas-free conditions.

Strategic Approach to the Metamorphosis of γ-Lactones to NH γ-Lactams via Reductive Cleavage and C-H Amidation

A new approach has elaborated on the conversion of γ-lactones to the corresponding NH γ-lactams that can serve as γ-lactone bioisosteres. This approach consists of reductive C-O cleavage and an Ir-catalyzed C-H amidation, offering a powerful synthetic tool for accessing a wide range of valuable NH γ-lactam building blocks starting from γ-lactones. The synthetic utility was further demonstrated by the late-stage transformation of complex bioactive molecules and the asymmetric transformation.

Quinoxaline-fused dibenzosuberane based helicenes and organic electroluminescent device using the same

A quinoxaline-fused dibenzosuberane based helicene is shown in formula (1), wherein A is with a structure of formula (2), formula (3a) or formula (3b); X is an oxygen atom, sulfur atom, amino group, or —(CH2)n, wherein n is 0, 1, or 2; R1 and R2 are independently selected from the group consisting of hydrogen atom, halogen atom, formula (4), formula (5) and formula (6); and R3 to R15 are independently selected from the group consisting of hydrogen atom, halogen atom, cyano group, alkyl group, cycloalkyl group, alkoxy group, thioalkyl group, silyl group, alkenyl group, aryl group, heteroaryl group, and amino group.

Synthesis, properties, and two-dimensional adsorption characteristics of 5-amino[6]hexahelicene

A convergent synthesis of racemic 5-amino[6]hexahelicene is described. Cross-coupling reactions are used to assemble a pentacyclic framework, and a metal-catalyzed ring-closure comprises the final step. The enantiomers were separated by means of chromatography and the absolute configurations were assigned by comparison of the CD spectra with hexahelicene. The t1/2 value for racemization at 210 °C was approximately 1 hour. Scanning tunneling microscopy (STM) measurements were carried out on enantiopure and racemic samples of aminohelicene on Au(111) under ultrahigh vacuum (UHV) conditions. Stairway to heaven? In a convergent synthesis of racemic 5-amino[6]hexahelicene (see figure), cross-coupling reactions assemble a pentacyclic framework, with a metal-catalyzed ring closure as the final step. The enantiomers are separated by means of chromatography and the absolute configurations assigned by comparison of the CD spectra with hexahelicene. Furthermore, scanning tunneling microscopy (STM) on Au(111) was performed under ultrahigh vacuum.

Methyl Hydrazinocarboxylate as a Practical Alternative to Hydrazine in the Wolff-Kishner Reaction

Herein we describe a facile protocol for the reduction of aromatic ketones and aldehydes to the corresponding methylene unit. The procedure involves isolation of a carbomethoxyhydrazone intermediate that is easily decomposed to the reduced product without the requirement for large quantities of pernicious hydrazine.

SYNTHESIS OF SUBSTITUTED TETRAHYDROINDENYL COMPLEXES

This invention relates to the synthesis of substituted tetrahydroindenyls and the use of the synthesised complexes in the homo- and co-polymerisation of ethylene and alpha-olefins.

NIACIN RECEPTOR AGONISTS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT

The present invention relates to niacin receptor agonists of formula: (I); as well as pharmaceutically acceptable salts and solvates. The compounds are useful for treating dyslipidemias, and in particular, reducing serum LDL, VLDL and triglycerides, and raising HDL levels. Pharmaceutical compositions and methods of treatment are also included.