Methyl 5-bromo-2-methoxy-3-nitrobenzoate

Base Information

• Chemical Name: Methyl 5-bromo-2-methoxy-3-nitrobenzoate
• CAS No.: 67657-90-3
• Molecular Formula: C9H8BrNO5
• Molecular Weight: 290.07
• Hs Code.: 2918990090
• Mol file: 67657-90-3.mol

Synonyms:Methyl-2-methoxy-3-nitro-5-bromobenzoat;5-bromo-2-methoxy-3-nitro-benzoic acid methyl ester;QC-5497;

Chemical Property of Methyl 5-bromo-2-methoxy-3-nitrobenzoate

Chemical Property:

• PSA: 81.35000
• LogP: 2.67570
• Storage Temp.: 2-8°C

Purity/Quality:

98%+ ^*data from raw suppliers

Methyl 5-bromo-2-methoxy-3-nitrobenzoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl 5-bromo-2-methoxy-3-nitrobenzoate

There total 5 articles about Methyl 5-bromo-2-methoxy-3-nitrobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

5-bromo-2-methoxy-3-nitro-benzoic acid (60541-89-1) + dimethyl sulfate (77-78-1) → 5-bromo-2-methoxy-3-nitro-benzoic acid methyl ester (67657-90-3)

Guidance literature:

With potassium carbonate; In acetone; for 6h; Reflux;

DOI:10.1016/j.ejmech.2014.01.053

Reference yield: 76.1%

5-bromo-2-methoxy-3-nitro-benzoic acid (60541-89-1) + methyl iodide (74-88-4) → 5-bromo-2-methoxy-3-nitro-benzoic acid methyl ester (67657-90-3)

Guidance literature:

With potassium carbonate; In acetone; for 3h; Heating;

DOI:10.1021/jo062032w

Reference yield:

5-bromosalicyclic acid (89-55-4) → 5-bromo-2-methoxy-3-nitro-benzoic acid methyl ester (67657-90-3)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium hydroxide

2: 75.3 percent / sulfuric acid; nitric acid / 0.5 h

3: 76.1 percent / potassium carbonate / acetone / 3 h / Heating

With potassium hydroxide; sulfuric acid; nitric acid; potassium carbonate; In acetone;

DOI:10.1021/jo062032w

upstream raw materials:

5-bromo-2-methoxy-3-nitro-benzoic acid

methyl iodide

5-bromosalicyclic acid

5-bromo-2-methoxybenzoic acid

Downstream raw materials:

3-amino-5-bromo-2-methoxy-benzoic acid methyl ester

5-bromo-3-(cyclopropanesulfonylamino)-2-methoxybenzamide

methyl 5-bromo-2-methoxy-3-(4-fluorophenylsulfonamino)benzoate

3-cyclopropylsulfonamino-2-methoxy-5-(4-morpholinoquinazolin-6-yl)benzamide

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