11-Dodecynoic acid methyl ester

Base Information

• Chemical Name: 11-Dodecynoic acid methyl ester
• CAS No.: 24567-43-9
• Molecular Formula: C13H22 O2
• Molecular Weight: 210.316
• Hs Code.: 2916190090
• Mol file: 24567-43-9.mol

Synonyms:NSC 151919

Chemical Property of 11-Dodecynoic acid methyl ester

Chemical Property:

• Vapor Pressure: 0.00932mmHg at 25°C
• Boiling Point: 265.1°Cat760mmHg
• Flash Point: 105°C
• PSA: 26.30000
• Density: 0.912g/cm³
• LogP: 3.30350

Purity/Quality:

99% ^*data from raw suppliers

Methyldodec-11-ynoate 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 11-Dodecynoic acid methyl ester

There total 10 articles about 11-Dodecynoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

methanol (67-56-1) + dodec-11-ynoic acid (16900-60-0) → 11-dodecynoic acid methyl ester (24567-43-9)

Guidance literature:

With sulfuric acid; for 16h; Reflux;

Reference yield:

1,12-dodecandiol (5675-51-4) → 11-dodecynoic acid methyl ester (24567-43-9)

Guidance literature:

Multi-step reaction with 5 steps

1: 1.) 48 percent HBr, concd. H₂SO₄; 2.) KMnO₄ / 1.) 3 h, reflux; 2.) 20percent H₂SO₄, 15-20 deg C

3: 75 percent / NaBH₄ / ethanol / 13 h / Ambient temperature

4: 82 percent / aq. H₂O₂ / tetrahydrofuran / 24 h

With sodium tetrahydroborate; potassium permanganate; sulfuric acid; hydrogen bromide; dihydrogen peroxide; In tetrahydrofuran; ethanol;

DOI:10.1246/bcsj.59.3535

Reference yield:

12-bromododecanoic acid (73367-80-3) → 11-dodecynoic acid methyl ester (24567-43-9)

Guidance literature:

Multi-step reaction with 4 steps

2: 75 percent / NaBH₄ / ethanol / 13 h / Ambient temperature

3: 82 percent / aq. H₂O₂ / tetrahydrofuran / 24 h

With sodium tetrahydroborate; dihydrogen peroxide; In tetrahydrofuran; ethanol;

DOI:10.1246/bcsj.59.3535

upstream raw materials:

methyl 11-dodecenoate

methanol

dodec-11-ynoic acid

11-dodecyn-1-ol

Downstream raw materials:

(11E,13E)-15-hydroxyeicosa-11,13-dienoic acid

dodec-11-ynoic acid

(11E,13Z)-15-hydroxyeicosa-11,13-dienoic acid