262293-82-3

Usage

InChI:InChI=1/C7H14O4/c1-4-11-6(8)5-7(9-2)10-3/h7H,4-5H2,1-3H3

Upstream product

• 67-56-1 methanol 
• 140-88-5 ethyl acrylate 
• 623-47-2 propynoic acid ethyl ester 
• 141-78-6 ethyl acetate 
• 149-73-5 trimethyl orthoformate 
• 75239-80-4 ethanol hydrochloride 

Downstream Products

• 721-01-7 1-(benzyloxy)uracil 
• 944896-82-6 5-chloro-imidazo[1,2-a]pyrimidine 
• 66-22-8 uracil 
• 94135-47-4 1-ethoxycarbonylmethyl-1,2,3,4-tetrahydro-β-carboline 

Relevant academic research and scientific papers

Green preparation method of uracil

The invention relates to a green preparation method of uracil, which comprises the following steps: proportionally mixing acetate, alkali and a benzene solvent in a reaction bottle to obtain a mixed solution, introducing carbon monoxide, pressurizing to generate aldehyde, adding a hydrogen chloride alcohol solution into the reaction bottle, and carrying out condensation reaction on aldehyde and the hydrogen chloride alcohol solution to obtain acetal, and adding urea into the reaction bottle, reacting acetal with urea to obtain a condensate, adding alkali into the reaction bottle, reacting alkali with the condensate to generate uracil sodium salt, adding acidic water into the reaction bottle, crystallizing, cooling, and filtering to obtain uracil. Carbon monoxide and acetate are innovatively used as raw materials, alkali such as sodium methoxide is used for one-pot catalytic synthesis of uracil, the synthesis method in the whole process is mild in condition, simple in process and high in yield and purity, the purposes of few three wastes and environmental protection are achieved, and the method has a good large-scale application prospect.

Preparation method of uracil

The invention belongs to the technical field of organic synthesis, and concretely relates to a preparation method of uracil. The preparation method of uracil is characterized in that the uracil is obtained by condensing and cyclizing a compound represented by formula (I) with urea in the presence of an alkali; the formula (I) is shown in the description, and in the formula (I), R is a C1-3 alkyl group, and R1 is a methyl group or an ethyl group; and the compound of formula (I) is prepared from orthoformate and acetate under the action of the alkali. The method for synthesizing uracil from theorthoformate and acetate in a one-pot manner is reported for the first time; and the method has the advantages of cheap and easily available raw materials, simple process, convenience in operation, simplification of the post-treatment process due to the same alkali in the two steps, mild and easily controlled reaction product, no special devices, meeting of industrial mass production requirements,and good industrial application values.

Atom-economical synthesis of 3,3,3-trifluoropropanal dialkyl acetals through Pd/C catalyzed acetalization of 3,3,3-trifluoropropene

A facile and efficient procedure for one-step synthesis of 3,3,3-trifluoropropanal dialkyl acetals from readily available 3,3,3-trifluoropropene (TFP) has been developed. The catalyst can be recycled for 4 times without obvious deactivation. This process provides a novel and atom-economical synthetic strategy for the preparation of functional CF3-containing compounds.

Platinum- and gold-catalyzed hydroalkoxylation and tetramerization of propiolate esters

PtCl2 was found to efficiently catalyze intermolecular additions of propiolate esters with alcohols. The reaction of propiolate esters and alcohols in the presence of PtCl2 gave (E)-vinyl ethers as the major products at 60 °C, whereas alkyl 3,3-dialkoxypropanoates were predominantly obtained when the reaction temperature was set to 80°C. On the other hand, a novel regioselective tetramerization of propiolate esters catalyzed by AuCl3 under mild conditions afforded 1,2,5,6-tetrasubstituted- cyclooctatetraene (1,2,5,6-COT) in moderate yields.

Palladium-catalyzed aerobic oxidation of terminal olefins with electron-withdrawing groups in scCO2

Product control of palladium-catalyzed aerobic oxidation of terminal olefins with electron-withdrawing groups can be achieved through modifying reaction conditions. When the oxidant, such as CuCl2/O2, benzoquinone/O2 or O2, was present in scCO2, aerobic oxidation of terminal olefins goes smoothly. With enough MeOH and sufficient oxygen, acetalization preponderated over cyclotrimerization, while with little MeOH as co-solvent in scCO2 or no MeOH in DMF and an appropriate pressure of O2, cyclotrimerization of terminal olefins became the dominated reaction. When oxygen is absent and triethylamine was added into the reaction system, palladium-catalyzed C-N bond formation occurs to produce β-amino acid derivatives as the sole product.

Pd(II)-catalyzed acetalization of terminal olefins with electron-withdrawing groups in supercritical carbon dioxide: selective control and mechanism

Pd(II)-catalyzed acetalization of terminal olefins with electron-withdrawing groups was carried out smoothly in supercritical carbon dioxide under oxygen atmosphere when polystyrene-supported benzoquinone (PS-BQ) or CuII (CuI) chloride was employed as cocatalyst. The higher selectivity was achieved, without any chlorinated by-product detected, when using PS-BQ instead of CuII (or CuI) chloride. PS-BQ could be recycled with excellent catalytic activity remaining after each simple filtration. Chlorine ion was demonstrated to be a promoter. The different acetalization mechanisms were revealed by the subtle relationship of chlorine ion and benzoquinone (BQ) to the catalytic activity of PdCl2/PS-BQ, PdII-CuCl2 or Pd(OAc)2/PS-BQ.

Acetalization of alkenes catalyzed by Pd(OAc)2/NPMoV supported on activated carbon under a dioxygen atmosphere

(Formula presented) The acetalization of terminal alkenes such as ethyl acrylate and acrylonitrile with alcohols under O2 was efficiently achieved by Pd(OAc)2 supported on activated carbon combined with molybdovanadophosphate (NPMoV). For example, ethyl acrylate was subjected to acetalization with EtOH acidified by CH3SO3H under O2 (1 atm) in the presence of [8 wt%Pd(OAc)2/C] and NPMoV to form ethyl 3,3-diethoxypropionate in quantitative yield.