4-(2-Ethoxy-5-methyl-4-nitrophenyl)morpholine

Base Information

• Chemical Name: 4-(2-Ethoxy-5-methyl-4-nitrophenyl)morpholine
• CAS No.: 68084-63-9
• Molecular Formula: C₁₂H₂₄O
• Molecular Weight: 184.322
• European Community (EC) Number: 268-449-7
• UNII: Z3D2LKK9CR
• DSSTox Substance ID: DTXSID6071081
• Nikkaji Number: J289.046A
• Wikidata: Q81998588
• Mol file: 68084-63-9.mol

Synonyms:4-(2-Ethoxy-5-methyl-4-nitrophenyl)morpholine;68084-63-9;Morpholine, 4-(2-ethoxy-5-methyl-4-nitrophenyl)-;EINECS 268-449-7;N-(2-Ethoxy-5-methyl-4-nitrophenyl)morpholine;Z3D2LKK9CR;UNII-Z3D2LKK9CR;DTXSID6071081;SCHEMBL24756513

Chemical Property of 4-(2-Ethoxy-5-methyl-4-nitrophenyl)morpholine

Chemical Property:

• Vapor Pressure: 3.5E-08mmHg at 25°C
• Boiling Point: 447°Cat760mmHg
• Flash Point: 224.1°C
• PSA: 67.52000
• Density: 1.202g/cm³
• LogP: 2.72670
• XLogP3: 2.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 3
• Exact Mass: 266.12665706
• Heavy Atom Count: 19
• Complexity: 302

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CCOC1=C(C=C(C(=C1)[N+](=O)[O-])C)N2CCOCC2

Technology Process of 4-(2-Ethoxy-5-methyl-4-nitrophenyl)morpholine

There total 31 articles about 4-(2-Ethoxy-5-methyl-4-nitrophenyl)morpholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

ethyl 2-(diphenylmethylsilyl)decanoate (89638-16-4) + ethyl iodide (75-03-6) → 3-dodecanone (1534-27-6) + 3-Ethyldodec-3-ene (68066-08-0)

Guidance literature:

With potassium tert-butylate; magnesium; Yield given. Multistep reaction;

DOI:10.1021/jo00196a033

Reference yield: 69.0%

dodecan-3-ol (10203-30-2) → 3-dodecanone (1534-27-6)

Guidance literature:

With 2,2,6,6-tetramethyl-piperidine-N-oxyl; dimethylsulfide; oxygen; copper(I) bromide dimethylsulfide complex; 6,6'-bis(C₈F₁₇(CH₂)4)-2,2'-bipyridine; In chlorobenzene; at 90 ℃;

DOI:10.1016/S0040-4020(02)00250-8

Reference yield: 69.0%

dodecan-3-ol (10203-30-2) + methyllithium (917-54-4) → 3-dodecanone (1534-27-6)

Guidance literature:

With oxygen; 2,2,6,6-tetramethyl-piperidine-N-oxyl; copper(I) bromide dimethylsulfide complex; bis(3-(perfluorooctyl)butyl)-2,2'-bipyridine; In chlorobenzene; at 90 ℃; for 3h;

DOI:10.1016/S0040-4039(00)00620-1

upstream raw materials:

1-iodononane

1-hydroxydodecan-3-one

propionyl chloride

n-decanoyl chloride

Refernces

• 1、 Glinski,Gibka. "Catalytic ketonisation over oxide catalysts. Part IX. Single step synthesis of aliphatic saturated and unsaturated C11 - C 13 ketones from carboxylic acids". . p. 299 - 302. Retrieved 2007/10/03.
• 2、 Betzemeier, Bodo,Cavazzini, Marco,Quici, Silvio,Knochel, Paul. "Copper-catalyzed aerobic oxidation of alcohols under fluorous biphasic conditions". . p. 4343 - 4346. Retrieved 2007/10/03.