(2-amino-5-bromophenyl)(4-chlorophenyl)methanone

Base Information

• Chemical Name: (2-amino-5-bromophenyl)(4-chlorophenyl)methanone
• CAS No.: 65246-99-3
• Molecular Formula: C13H9BrClNO
• Molecular Weight: 310.578
• Hs Code.: 2922399090
• Mol file: 65246-99-3.mol

Synonyms:5-Brom-4'-chlor-2-amino-benzophenon;2-Amino-5-brom-4'-chlor-benzophenon;

Chemical Property of (2-amino-5-bromophenyl)(4-chlorophenyl)methanone

Chemical Property:

• Vapor Pressure: 1.34E-08mmHg at 25°C
• Boiling Point: 458.7°Cat760mmHg
• Flash Point: 231.2°C
• PSA: 43.09000
• Density: 1.568g/cm³
• LogP: 4.49690

Purity/Quality:

95% ^*data from raw suppliers

(2-Amino-5-bromophenyl)(4-chlorophenyl)methanone 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (2-amino-5-bromophenyl)(4-chlorophenyl)methanone

There total 9 articles about (2-amino-5-bromophenyl)(4-chlorophenyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

2-amino-4'-chlorobenzophenone (2894-51-1) → (2-amino-5-bromo-phenyl)-(4-chloro-phenyl)methanone (65246-99-3)

Guidance literature:

With N-Bromosuccinimide; In dichloromethane; at 0 - 20 ℃;

Reference yield: 78.0%

5-bromo-3-(4-chlorophenyl)-2,1-benzisoxazole (887-90-1) → (2-amino-5-bromo-phenyl)-(4-chloro-phenyl)methanone (65246-99-3)

Guidance literature:

With samarium; iodine; In tetrahydrofuran; at 20 ℃; for 0.0833333h;

DOI:10.1016/S0040-4039(02)01583-6

Reference yield: 33.0%

4-Cyanochlorobenzene (623-03-0) + 4-bromo-aniline (106-40-1) → (2-amino-5-bromo-phenyl)-(4-chloro-phenyl)methanone (65246-99-3)

Guidance literature:

4-Cyanochlorobenzene; 4-bromo-aniline; With gallium(III) trichloride; boron trichloride; In methanol; dichloromethane; 1,2-dichloro-ethane; at 90 ℃;

With water; In methanol; dichloromethane; 1,2-dichloro-ethane; at 80 ℃; for 0.5h;

DOI:10.1016/j.tet.2007.01.050

upstream raw materials:

4-chloro-benzoyl chloride

4-bromo-aniline

5-bromo-3-(4-chlorophenyl)-2,1-benzisoxazole

4-Cyanochlorobenzene

Downstream raw materials:

C₁₈H₁₃BrClNO₂

C₁₈H₁₅BrClNO₄

C₁₉H₁₅BrClNO₃

C₁₇H₁₁BrClNO₃