(E)-3-(2,5-difluorophenyl)prop-2-en-1-ol

Base Information

• Chemical Name: (E)-3-(2,5-difluorophenyl)prop-2-en-1-ol
• CAS No.: 767355-26-0
• Molecular Formula: C9H8F2O
• Molecular Weight: 170.159
• Mol file: 767355-26-0.mol

Synonyms:(2E)-3-(2,5-difluorophenyl)-2-propen-1-ol;(E)-3-(2,5-difluoro-phenyl)-prop-2-en-1-ol;2,5-difluorocinnamyl alcohol;(E)-3-(2,5-difluorophenyl)-prop-2-en-1-ol;(2E)-3-(2,5-difluorophenyl)prop-2-en-1-ol;

Chemical Property of (E)-3-(2,5-difluorophenyl)prop-2-en-1-ol

Chemical Property:

• PSA: 20.23000
• LogP: 1.97030

Purity/Quality:

99% ^*data from raw suppliers

(E)-3-(2,5-difluorophenyl)prop-2-en-1-ol 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (E)-3-(2,5-difluorophenyl)prop-2-en-1-ol

There total 3 articles about (E)-3-(2,5-difluorophenyl)prop-2-en-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

ethyl (E)-3-(2,5-difluorophenyl)acrylate (375368-91-5,881658-90-8) → trans-3-(2,5-difluoro-phenyl)-prop-2-en-1-ol (767355-26-0)

Guidance literature:

ethyl (E)-3-(2,5-difluorophenyl)acrylate; With diisobutylaluminium hydride; In diethyl ether; hexane; at 0 ℃; for 0.666667h;

With water; In diethyl ether; hexane; for 0.5h;

Reference yield: 82.0%

3-(2,5-difluorophenyl)acrylic acid (112898-33-6) → trans-3-(2,5-difluoro-phenyl)-prop-2-en-1-ol (767355-26-0)

Guidance literature:

3-(2,5-difluorophenyl)acrylic acid; With N-ethyl-N,N-diisopropylamine; isobutyl chloroformate; In tetrahydrofuran; at 20 ℃; for 0.5h;

With lithium borohydride; In tetrahydrofuran; at 0 - 20 ℃; for 1h;

With hydrogenchloride; water; In tetrahydrofuran; at 0 ℃; pH=7;

Reference yield:

methyl (2E)-3-(2,5-difluorophenyl)-2-propenoate (1007862-01-2) → trans-3-(2,5-difluoro-phenyl)-prop-2-en-1-ol (767355-26-0)

Guidance literature:

methyl (2E)-3-(2,5-difluorophenyl)-2-propenoate; With diisobutylaluminium hydride; In dichloromethane; toluene; at -78 ℃; for 0.666667h;

With methanol; acetic acid; In dichloromethane; toluene;

upstream raw materials:

ethyl (E)-3-(2,5-difluorophenyl)acrylate

3-(2,5-difluorophenyl)acrylic acid

methyl (2E)-3-(2,5-difluorophenyl)-2-propenoate

Downstream raw materials:

(E)-3-(2,5-difluorophenyl)acrylaldehyde

2-[(1E)-3-chloroprop-1-en-1-yl]-1,4-difluorobenzene

(E)-3-(2,5-difluorophenyl)allyl acetate

(1R)-1-[(4-{[(2E)-3-(2,5-difluorophenyl)-2-propen-1-yl]amino}-1-piperidinyl)methyl]-9-fluoro-1,2-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-4-one