tert-butyl {1-[(2E)-3-(2,5-difluorophenyl)prop-2-en-1-yl]piperidin-4-yl}carbamate

Base Information

Chemical Name:tert-butyl {1-[(2E)-3-(2,5-difluorophenyl)prop-2-en-1-yl]piperidin-4-yl}carbamate
CAS No.:917343-02-3
Molecular Formula:C₁₉H₂₆F₂N₂O₂
Molecular Weight:352.424
Hs Code.:

Synonyms:tert-butyl {1-[(2E)-3-(2,5-difluorophenyl)prop-2-en-1-yl]piperidin-4-yl}carbamate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of tert-butyl {1-[(2E)-3-(2,5-difluorophenyl)prop-2-en-1-yl]piperidin-4-yl}carbamate

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Technology Process of tert-butyl {1-[(2E)-3-(2,5-difluorophenyl)prop-2-en-1-yl]piperidin-4-yl}carbamate

There total 3 articles about tert-butyl {1-[(2E)-3-(2,5-difluorophenyl)prop-2-en-1-yl]piperidin-4-yl}carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 149946-42-9
2-[(1E)-3-chloroprop-1-en-1-yl]-1,4-difluorobenzene

: 73874-95-0
(piperidin-4-yl)carbamic acid tert-butyl ester

: 917343-02-3
tert-butyl {1-[(2E)-3-(2,5-difluorophenyl)prop-2-en-1-yl]piperidin-4-yl}carbamate

Guidance literature:: With potassium carbonate; In ethanol; at 80 ℃; for 18h;

Reference yield:

: 767355-26-0
trans-3-(2,5-difluoro-phenyl)-prop-2-en-1-ol

: 917343-02-3
tert-butyl {1-[(2E)-3-(2,5-difluorophenyl)prop-2-en-1-yl]piperidin-4-yl}carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / 1,4-dioxane; water / 3 h / 100 °C / Microwave irradiation

2: potassium carbonate / ethanol / 18 h / 80 °C

With hydrogenchloride; potassium carbonate; In 1,4-dioxane; ethanol; water;

Reference yield:

: 112898-33-6
3-(2,5-difluorophenyl)acrylic acid

: 917343-02-3
tert-butyl {1-[(2E)-3-(2,5-difluorophenyl)prop-2-en-1-yl]piperidin-4-yl}carbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine; isobutyl chloroformate / tetrahydrofuran / 0.5 h / 20 °C

1.2: 1 h / 0 - 20 °C

1.3: 0 °C / pH 7

2.1: hydrogenchloride / 1,4-dioxane; water / 3 h / 100 °C / Microwave irradiation

3.1: potassium carbonate / ethanol / 18 h / 80 °C

With hydrogenchloride; potassium carbonate; N-ethyl-N,N-diisopropylamine; isobutyl chloroformate; In tetrahydrofuran; 1,4-dioxane; ethanol; water;