Formylmethionyl-leucyl-phenylalanine methyl ester

Base Information

• Chemical Name: Formylmethionyl-leucyl-phenylalanine methyl ester
• CAS No.: 65929-03-5
• Molecular Formula: C₂₂H₃₃N₃O₅S
• Molecular Weight: 451.587
• DSSTox Substance ID: DTXSID20984419
• Nikkaji Number: J475.877C
• Wikidata: Q27106668
• Metabolomics Workbench ID: 68139
• ChEMBL ID: CHEMBL285518
• Mol file: 65929-03-5.mol

Synonyms:f-Met-Leu-Phe-OMe;FMLP OMe;For-Met-Leu-Phe-OMe;formyl-Met-Leu-Phe OMe;formyl-methionyl-leucyl-phenylalanine methyl ester;formylmethionyl-leucyl-phenylalanine methyl ester;HCO-Met-Leu-Phe-Ome

Chemical Property of Formylmethionyl-leucyl-phenylalanine methyl ester

Chemical Property:

• Vapor Pressure: 1.66E-21mmHg at 25°C
• Boiling Point: 735.7 °C at 760 mmHg
• Flash Point: 398.7 °C
• PSA: 138.90000
• Density: 1.156 g/cm³
• LogP: 3.09410
• Storage Temp.: -15°C
• XLogP3: 1.8
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 14
• Exact Mass: 451.21409234
• Heavy Atom Count: 31
• Complexity: 582

Purity/Quality:

98%Min ^*data from raw suppliers

N-FORMYL-MET-LEU-PHE METHYL ESTER 98.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)CC(C(=O)NC(CC1=CC=CC=C1)C(=O)OC)NC(=O)C(CCSC)NC=O
• Isomeric SMILES: CC(C)C[C@@H](C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)OC)NC(=O)[C@H](CCSC)NC=O

Technology Process of Formylmethionyl-leucyl-phenylalanine methyl ester

There total 5 articles about Formylmethionyl-leucyl-phenylalanine methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

methanol (67-56-1) + CHO-Met-Leu-Phe-O-t-Bu (99880-61-2) → N-formylmethionylleucylphenylalanine methyl ester (77543-00-1,65929-03-5)

Guidance literature:

With cross-linked enzyme aggregates of Alcalase; at 50 ℃; for 48h; Molecular sieve; Enzymatic reaction;

DOI:10.1002/adsc.201000313

Reference yield: 93.0%

formic acid pentafluorophenyl ester (111333-97-2) + H-Met-Leu-Phe-OCH3 (111333-96-1) → N-formylmethionylleucylphenylalanine methyl ester (77543-00-1,65929-03-5)

Guidance literature:

In chloroform; Ambient temperature;

DOI:10.1055/s-1987-27987

Reference yield: 87.0%

H-Met-Leu-Phe-OCH3 (111333-96-1) + (formyloxy)(acetoxy)phenylmethane (113388-44-6) → N-formylmethionylleucylphenylalanine methyl ester (77543-00-1,65929-03-5)

Guidance literature:

In ethyl acetate; at 20 ℃; for 5h;

DOI:10.1021/acs.orglett.7b02382

upstream raw materials:

formic acid pentafluorophenyl ester

H-Met-Leu-Phe-OCH₃

H-Met-Leu-Phe-OMe formate salt

Boc-Met-Leu-Phe-OMe

Downstream raw materials:

C₂₂H₃₄N₄O₅S

C₂₃H₃₆N₄O₅S

C₂₃H₃₃N₅O₄S

formyl-methionyl-leucyl-phenylalanine