Methyl lactate

Base Information

• Chemical Name: Methyl lactate
• CAS No.: 547-64-8
• Deprecated CAS: 2155-30-8
• Molecular Formula: C4H8O3
• Molecular Weight: 104.106
• Hs Code.: 29181100
• European Community (EC) Number: 208-930-0,218-449-8
• NSC Number: 406248
• UNII: H10S91526X
• DSSTox Substance ID: DTXSID0027197
• Nikkaji Number: J2.650F
• Wikipedia: Methyl_lactate
• Wikidata: Q11370589
• Metabolomics Workbench ID: 66597
• ChEMBL ID: CHEMBL3183351
• Mol file: 547-64-8.mol

Synonyms:methyl 2-hydroxypropionate;methyl lactate;methyl lactate, (+)-isomer;methyl lactate, (+-)-isomer;methyl lactate, (S)-isomer

Chemical Property of Methyl lactate

Chemical Property:

• Appearance/Colour: clear colorless liquid
• Vapor Pressure: 1.93mmHg at 25°C
• Melting Point: -66°C
• Refractive Index: n20/D 1.413
• Boiling Point: 145.3 °C at 760 mmHg
• PKA: 13.07±0.20(Predicted)
• Flash Point: 47.1 °C
• PSA: 46.53000
• Density: 1.085 g/cm³
• LogP: -0.45980
• Storage Temp.: Flammables area
• Sensitive.: Moisture Sensitive
• Water Solubility.: miscible, hydrolyses
• XLogP3: -0.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 104.047344113
• Heavy Atom Count: 7
• Complexity: 69.3

Purity/Quality:

98% ^*data from raw suppliers

Methyl DL-Lactate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 10-36/37
• Safety Statements: 24-24/25

MSDS Files:

SDS file from LookChem

Useful:

• Chemical Classes: Solvents -> Esters (
• Canonical SMILES: CC(C(=O)OC)O
• Uses: Methyl lactate is used as a solvent for nitrocellulose, cellulase acetate, cellulase acetobutyrote and cellulase acetaprapionate. It is used in the manufacture of lacquers and dopes where it contributes high tolerance for diluents, good flaw and blush resistance.

Technology Process of Methyl lactate

There total 184 articles about Methyl lactate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

pyruvic acid methyl ester (600-22-6) → methyl lactate (547-64-8,2155-30-8)

Guidance literature:

With magnesium(II) perchlorate; polymer-bound NADH (2a); In acetonitrile; benzene; at 80 ℃; for 120h; Further byproducts given;

DOI:10.1016/S0040-4039(00)85780-9

Reference yield: 96.0%

methanol (67-56-1) + glycerol (56-81-5,25618-55-7,64333-26-2,8013-25-0) → methyl lactate (547-64-8,2155-30-8)

Guidance literature:

With phosphotungstic acid; at 130 ℃; for 4h; Reagent/catalyst; Autoclave; Inert atmosphere; Green chemistry;

Reference yield: 85.58%

methanol (67-56-1) + 2-hydroxy-propionitrile (78-97-7) → methyl lactate (547-64-8,2155-30-8)

Guidance literature:

With hydrogenchloride; water; at -10 - -5 ℃; for 4h; Reflux;

upstream raw materials:

methanol

LACTIC ACID

lactic acid anhydro sulfite

2-chloro-propionic acid methyl ester

Downstream raw materials:

N,N-hexamethylene lactamide

lactic acid tetrahydrofurfuryl ester

2-methoxycarbonyloxy-propionic acid methyl ester

n-propyl lactate

Refernces

• 1、 Chung, Iljun,Song, Byeongju,Kim, Jeongmyeong,Yun, Yongju. "Enhancing Effect of Residual Capping Agents in Heterogeneous Enantioselective Hydrogenation of α-keto Esters over Polymer-Capped Pt/Al2O3". . p. 31 - 42. Retrieved 2021/01/11.
• 2、 -. "Method for preparing methyl lactate through catalytic conversion of carbohydrate". Paragraph 0078-0079; 0095-0096. . Retrieved 2022/01/04.