Thiazole, 4,5-dihydro-2,5-dimethyl-

Base Information

• Chemical Name: Thiazole, 4,5-dihydro-2,5-dimethyl-
• CAS No.: 4146-19-4
• Molecular Formula: C5H9NS
• Molecular Weight: 115.199
• NSC Number: 48044
• Nikkaji Number: J2.109.306H
• Mol file: 4146-19-4.mol

Synonyms:Thiazole, 4,5-dihydro-2,5-dimethyl-;4146-19-4;2,5-dimethyl-4,5-dihydrothiazole;4,5-Dihydro-2,5-dimethylthiazole;BRN 0106260;NSC48044;4-27-00-00926 (Beilstein Handbook Reference);SCHEMBL762176;2,5-Dimethyl-delta2-thiazoline;2,5-Dimethyl-delta^2-thiazoline;NSC 48044;NSC-48044

Chemical Property of Thiazole, 4,5-dihydro-2,5-dimethyl-

Chemical Property:

• Vapor Pressure: 5.69mmHg at 25°C
• Boiling Point: 147.1°C at 760 mmHg
• Flash Point: 42.8°C
• Density: 1.13g/cm³
• XLogP3: 0.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 115.04557046
• Heavy Atom Count: 7
• Complexity: 98.3

Purity/Quality:

98%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1CN=C(S1)C

Technology Process of Thiazole, 4,5-dihydro-2,5-dimethyl-

There total 5 articles about Thiazole, 4,5-dihydro-2,5-dimethyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

N-(2-hydroxypropyl)-acetamide (4293-57-6) → 2,5-dimethylthiazoline (4146-19-4)

Guidance literature:

With sodium hydroxide; tetraphosphorus decasulfide;

DOI:10.1515/znb-1987-0317

Reference yield:

3-amino-2-propanol (78-96-6,1674-56-2) + acetyl chloride (75-36-5) → 2,5-dimethylthiazoline (4146-19-4)

Guidance literature:

3-amino-2-propanol; acetyl chloride; With triethylamine; In dichloromethane; at 0 ℃; for 0.5h;

With Lawessons reagent; In toluene; for 0.25h; Further stages.; Heating;

DOI:10.1016/j.tetlet.2004.09.182

Reference yield:

2-bromopropylamine hydrobromide (2403-33-0) + thioacetamide (62-55-5) → 2,5-dimethylthiazoline (4146-19-4)

Guidance literature:

at 135 ℃;

upstream raw materials:

2-bromopropylamine hydrobromide

thioacetamide

acetic acid

3-amino-2-propanol

Downstream raw materials:

1-(3,5-dimethylthiazolidin-2-ylidene)-3,3-dimethylbutan-2-one

1-amino-2-propanethiol hydrochloride

1-amino-2-propanethiol

N-benzoyl-glycine 2-[1-(5-oxo-2-phenyl-oxazol-4-ylidene)-ethylsulfanyl]-propylamide