2403-33-0Relevant academic research and scientific papers
Determination des pKa et reaction d'ouverture acide de quelques alkyl-2 et aryl-2 aziridines
Lamaty, Gerard,Sanchez, Jean-Yves,Sivade, Andre,Wylde, James
, p. 1261 - 1266 (2007/10/02)
Some 2-para substituted aryl aziridines (with pY = CH3O-, CH3-, H-, and Cl-) have been prepared.Their ring opening reaction in acidic medium has been studied and compared with those of two aliphatic aziridines : 2 methyl- and 2,2 dimethyl-aziridine.In aqueous solvent, the addition of HCl, HBr, and HI to the aromatic aziridines leads exclusively to the secondary halogen product, due to the nucleophilic attack on the benzylic carbon.The hydrolysis reaction competes with the addition reaction and is very important for the para methoxy 2-phenyl aziridine.In ethyl alcohol (anhydrous solvent), the hydrohalogenation reaction leads exclusively to halogeno amine with a secondary halogen.The solvolysis reaction, leading to amino-ether, is far less important than in water (excepted for the para methoxy 2-phenyl aziridine).In both solvents, the importance of the solvolysis depends on the HX concentration, as well as the nucleophilic strength of the halogen.The pKa values of these aziridines have been measured, as well as those of 2-phenyl 1-amino 2-ethanol.A linear plot is obtained for the pKa versus ?+p of Brown ; the slopes are respectively -2.8 and 0.Therefore the aromatic aziridines seem to have a behavior similar to that of anilines.
AMINOALKYLATION OF HYDRAZINE BY 2-HALOGENOPROPYLAMINE HYDROHALIDES
Surnin, V. A.,Zenkevich, I. G.,Lobanov, P. S.,Potekhin, A. A.
, p. 1997 - 2002 (2007/10/02)
By chromato-mass spectrometry it was shown that the aminoalkylation of hydrazine with 2-halogenopropylamine hydrohalides leads to the formation of a mixture of isomeric 2-amino-1-hydrazino- and 1-amino-2-hydrazinopropanes.The preferentially obtained deriv
