2-(1,2-Diphenylethylamino)-pyridine

Base Information

• Chemical Name: 2-(1,2-Diphenylethylamino)-pyridine
• CAS No.: 74037-48-2
• Molecular Formula: C19H18N2
• Molecular Weight: 274.365
• Hs Code.: 2933399090
• European Community (EC) Number: 654-221-8
• DSSTox Substance ID: DTXSID10995357
• Nikkaji Number: J66.599A
• ChEMBL ID: CHEMBL1524466
• Mol file: 74037-48-2.mol

Synonyms:74037-48-2;N-(1,2-diphenylethyl)pyridin-2-amine;2-(1,2-Diphenylethylamino)-pyridine;N-(1,2-diphenylethyl)-2-pyridinamine;BRN 0205132;2-(alpha-Phenylphenethylamino)pyridine;Pyridine, 2-((1,2-diphenylethyl)amino)-;N-(2-Pyridyl)-1,2-diphenylethanamine;4-22-00-03856 (Beilstein Handbook Reference);MLS000763607;CHEMBL1524466;DTXSID10995357;HMS2617D06;2-(1,2-Diphenylethylamino)pyridine;AKOS005081619;NCGC00246531-01;SMR000337184;2-Pyridinamine, N-(1,2-diphenylethyl)-;LS-131528;CS-0367597;12W-0870

Chemical Property of 2-(1,2-Diphenylethylamino)-pyridine

Chemical Property:

• Vapor Pressure: 1.53E-07mmHg at 25°C
• Boiling Point: 428.3°Cat760mmHg
• Flash Point: 212.9°C
• PSA: 24.92000
• Density: 1.139g/cm³
• LogP: 4.55050
• XLogP3: 4.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 5
• Exact Mass: 274.146998583
• Heavy Atom Count: 21
• Complexity: 279

Purity/Quality:

99% ^*data from raw suppliers

2-(1,2-DIPHENYLETHYLAMINO)-PYRIDINE Aldrich ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)CC(C2=CC=CC=C2)NC3=CC=CC=N3

Technology Process of 2-(1,2-Diphenylethylamino)-pyridine

There total 11 articles about 2-(1,2-Diphenylethylamino)-pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

2-phenyl-N-(pyridin-2-yl)acetamide (5223-01-8) + 5,5-dimethyl-2-phenyl-1,3,2-dioxaborinane (5123-13-7) → N-(1,2-diphenylethyl)pyridin-2-amine (74037-48-2)

Guidance literature:

With dodecacarbonyl-triangulo-triruthenium; isopropyl alcohol; at 140 ℃; for 24h; Inert atmosphere; Sealed tube;

DOI:10.1002/anie.201810947

Reference yield:

N-benzylidenepyridin-2-amine (1883-96-1,82299-15-8,88785-73-3) + benzylmagnesium chloride (6921-34-2) → N-(1,2-diphenylethyl)pyridin-2-amine (74037-48-2)

Guidance literature:

With Isopropylbenzene;

DOI:10.1021/ja01126a067

Reference yield:

N-(pyridin-2-yl)monomethyl terephthalate monoamide (923748-45-2) → N-(1,2-diphenylethyl)pyridin-2-amine (74037-48-2)

Guidance literature:

Multi-step reaction with 4 steps

1: dodecacarbonyl-triangulo-triruthenium; isopropyl alcohol / 24 h / 140 °C / Inert atmosphere; Sealed tube

2: hydrogenchloride / water / 16 h / 20 °C / Sealed tube

3: pyridine / 16 h / 0 - 20 °C / Inert atmosphere

4: dodecacarbonyl-triangulo-triruthenium; isopropyl alcohol / 24 h / 140 °C / Inert atmosphere; Sealed tube

With pyridine; hydrogenchloride; dodecacarbonyl-triangulo-triruthenium; isopropyl alcohol; In water;

DOI:10.1002/anie.201810947

upstream raw materials:

N-benzylidenepyridin-2-amine

benzylmagnesium chloride

2-aminopyridine

phenylacetyl chloride

Downstream raw materials:

2-aminopyridine

Chloro-1 diphenyl-1,2 ethane

4-chloro-N-(pyridine-2-yl)benzamide

N-(pyridin-2-yl)isonicotinamide