923748-45-2Relevant academic research and scientific papers
Direct Transformation of Alkylarenes into N-(Pyridine-2-yl)amides by C(sp3)–C(sp3) Bond Cleavage
Zhou, Haipin,Liu, Yanpeng,Xia, Haidong,Xu, Jinyi,Wang, Tingfang,Xu, Shengtao
, p. 6468 - 6473 (2020)
C(sp3)–H bond functionalization and C(sp3)–C(sp3) bond cleavage are very challenging transformations in chemistry. Herein, we report a mild and green methodology for the construction of N-(pyridine-2-yl)amides via tandem C(sp3)–H activation/C–C bond cleavage of alkylarenes. Various N-heterocyclic amides were directly synthesized from alkylarenes in water in moderate to good yields.
Co2(CO)8as a Solid CO (g) Source for the Amino Carbonylation of (Hetero)aryl Halides with Highly Deactivated (Hetero)arylamines
Cheruku, Srinivas,Sajith, Ayyiliath M.,Narayana, Yatheesh,Shetty, Poornima,Nagarakere, Sandhya C.,Sagar, Kunigal S,Manikyanally, Kumara N.,Rangappa, Kanchugarkoppal Subbegowda,Mantelingu, Kempegowda
, p. 5530 - 5537 (2021/05/07)
Carbonylation of (hetero)aryl iodides/bromides with highly deactivated 2-aminopyridines using Pd-Co(CO)4 bimetallic catalysis is accomplished. The use of Co2(CO)8 as a solid CO(g) source enhanced reaction rates observed when compared to CO(g), and excellent yields highlight the versatility of the developed protocol. A wide range of electronically and sterically demanding heterocyclic amines and (hetero)aryl iodides/bromides employed for this study resulted in excellent yields of amino carbonylated products. The developed methodology was further extended to synthesize Trypanosome brucie and luciferase inhibitors.
Ruthenium-Catalyzed Reductive Arylation of N-(2-Pyridinyl)amides with Isopropanol and Arylboronate Esters
Ronson, Thomas O.,Renders, Evelien,Van Steijvoort, Ben F.,Wang, Xubin,Wybon, Clarence C. D.,Prokopcová, Hana,Meerpoel, Lieven,Maes, Bert U. W.
, p. 482 - 487 (2019/01/04)
A new three-component reductive arylation of amides with stable reactants (iPrOH and arylboronate esters), making use of a 2-pyridinyl (Py) directing group, is described. The N-Py-amide substrates are readily prepared from carboxylic acids and PyNH2, and the resulting N-Py-1-arylalkanamine reaction products are easily transformed into the corresponding chlorides by substitution of the HN-Py group with HCl. The 1-aryl-1-chloroalkane products allow substitution and cross-coupling reactions. Therefore, a general protocol for the transformation of carboxylic acids into a variety of functionalities is obtained. The Py-NH2 by-product can be recycled.
Microwave-assisted heteropolyanion-based ionic liquid promoted sustainable protocol to N-heteroaryl amides via N-directing dual catalyzed oxidative amidation of aldehydes
Fu, Renzhong,Yang, Yang,Jin, Weihua,Gu, Hui,Zeng, Xiaojun,Chai, Wen,Ma, Yunsheng,Wang, Quan,Yi, Jun,Yuan, Rongxin
, p. 107699 - 107707 (2016/11/29)
A sustainable procedure for the synthesis of N-heteroaryl amides directly from oxidative amidation of aldehydes catalyzed by heteropolyanion-based ionic liquids under microwave-promoted conditions has been reported. The transformation has proven to tolerate a wide range of aldehydes and amino heterocycles with different functional groups. Moderate to excellent yields, solvent-free media, operational simplicity and reusability of catalysts are the main highlights. Furthermore, the proposed N-directing dual-catalysis mechanistic pathway was briefly investigated in this report.
Copper(i)-catalysed oxidative C-N coupling of 2-aminopyridine with terminal alkynes featuring a CC bond cleavage promoted by visible light
Ragupathi, Ayyakkannu,Sagadevan, Arunachalam,Lin, Chun-Cheng,Hwu, Jih-Ru,Hwang, Kuo Chu
supporting information, p. 11756 - 11759 (2016/10/07)
Facile visible-light promoted copper-catalyzed aerobic oxidative C-N coupling between 2-aminopyridine and terminal alkynes at room temperature via CC triple bond cleavage is described. This reaction allows direct synthesis of biologically important pyridy
Thermoplastic polymer composition
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, (2015/12/17)
The invention provides a compound conforming to the structure of Formula (C) The invention also provides a thermoplastic polymer composition comprising a polyolefin polymer and a compound conforming to the structure of Formula (C) as a nucleating agent.
THERMOPLASTIC POLYMER COMPOSITION
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, (2015/04/15)
The invention provides a thermoplastic polymer composition comprising a polyolefin polymer and a nucleating agent. The nucleating agent comprises a compound conforming to the structure of Formula (I). The invention also provides a series of compounds encompassed by the structure of Formula (I).
THERMOPLASTIC POLYMER COMPOSITION
-
, (2015/04/15)
The invention provides a compound conforming to the structure of Formula (CX). The invention also provides a thermoplastic polymer composition comprising a polyolefin polymer and a compound conforming to the structure of Formula (CX) as a nucleating agent.
Diverse Ag(I) complexes constructed from asymmetric pyridyl and pyrimidyl amide ligands: Roles of Ag...Ag and π-π Interactions
Hsiao, Hui-Lin,Wu, Chia-Jun,Hsu, Wayne,Yeh, Chun-Wei,Xie, Ming-Yuan,Huang, Wun-Jhih,Chen, Jhy-Der
, p. 8143 - 8152 (2013/01/15)
Reactions of silver(i) salts with the isomeric pyridyl amide ligands methyl-4-(pyridin-2-ylcarbamoyl)benzoate (L1), methyl-4-(pyridin-3- ylcarbamoyl)benzoate (L2) and methyl-4-(pyridin-4-ylcarbamoyl) benzoate (L3) and the pyrimidyl amide ligand methyl-4-(pyrimidin-2- ylcarbamoyl)benzoate (L4) afforded the complexes Ag 4(L1)4(NO3)4, 1, [Ag(L2)2][Ag(NO3)2], 2, [Ag(L 2)2](ClO4), 3, [Ag(L2) 2](ClO4)·2CH3CN, 4, [Ag(L 3)2](NO3), 5, [Ag(L3) 2](ClO4)·CH3CN, 6, and [Ag(L 4)2](X) (X = ClO4-, 7; BF 4-, 8; PF6-, 9), which were structurally characterized by X-ray crystallography. The L1-L 3 ligands in 1-6 adopt monodentate bonding modes, which coordinate to the metal centers through the pyridyl nitrogen atoms, whereas the L4 ligands of 7-9 adopt a bidentate mode, featuring chelation through one pyrimidyl nitrogen atom and the amide oxygen atom. All nine complexes adopt discrete structures with 1 being tetranuclear and 2-9 being mononuclear. Moreover, Ag...Ag short contacts, π...π stacking interactions and/or Ag...O interactions are found in these complexes which extend the dimensionalities of the structures. The changes of the donor atom positions and counteranions significantly affect the supramolecular structures of these complexes and the L1-L4 ligands are sufficiently flexible to adopt the cis and/or trans conformations.
