1-(2-Bromoethoxy)-2-nitrobenzene

Base Information

• Chemical Name: 1-(2-Bromoethoxy)-2-nitrobenzene
• CAS No.: 18800-37-8
• Molecular Formula: C8H8BrNO3
• Molecular Weight: 246.06
• Hs Code.: 29093038
• Mol file: 18800-37-8.mol

Synonyms:Phenetole, b-bromo-o-nitro- (7CI,8CI);1-(2-Bromoethoxy)-2-nitrobenzene;NSC 212493;

Chemical Property of 1-(2-Bromoethoxy)-2-nitrobenzene

Chemical Property:

• Vapor Pressure: 0.000158mmHg at 25°C
• Melting Point: 40-44 °C
• Refractive Index: 1.583
• Boiling Point: 341.5 °C at 760 mmHg
• Flash Point: 160.3 °C
• PSA: 55.05000
• Density: 1.587g/cm³
• LogP: 2.89170
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

98.5% ^*data from raw suppliers

1-(2-Bromoethoxy)-2-nitrobenzene ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn; Xi
• Hazard Codes: Xn,Xi
• Statements: 36/37/38-22
• Safety Statements: 37/39-26

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(2-Bromoethoxy)-2-nitrobenzene

There total 4 articles about 1-(2-Bromoethoxy)-2-nitrobenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

ethylene dibromide (106-93-4) + 2-hydroxynitrobenzene (88-75-5,78813-12-4) → 1-(2-bromoethoxy)-2-nitrobenzene (18800-37-8)

Guidance literature:

With potassium carbonate; In acetonitrile; for 2h; Reflux;

Reference yield:

sodium o-nitrophenate (824-39-5) + ethylene dibromide (106-93-4) → 1-(2-bromoethoxy)-2-nitrobenzene (18800-37-8)

Guidance literature:

With ethanol;

Reference yield:

1-Bromo-2-chloroethane (107-04-0) + 2-hydroxynitrobenzene (88-75-5,78813-12-4) → 1-(2-bromoethoxy)-2-nitrobenzene (18800-37-8) + 1-(2-chloroethoxy)-2-nitrobenzene (102236-25-9)

Guidance literature:

2-hydroxynitrobenzene; With potassium carbonate; In N,N-dimethyl-formamide;

1-Bromo-2-chloroethane; With potassium iodide; In N,N-dimethyl-formamide; Heating;

DOI:10.1002/ejoc.202100948

upstream raw materials:

sodium o-nitrophenate

ethylene dibromide

2-hydroxynitrobenzene

1-Bromo-2-chloroethane

Downstream raw materials:

(2-bromo-ethyl)-(4-chloromethyl-2-nitro-phenyl)-ether

2-[2-(2-nitro-phenoxy)-ethoxy]-benzoic acid

1,5-bis(2-nitrophenoxy)-3-azapentane

C₆₂H₇₄N₂O₁₀

Refernces

• 1、 Takaoka, Yousuke,Shigenaga, Miyuki,Imai, Masaki,Nukadzuka, Yuuki,Ishimaru, Yasuhiro,Saito, Kei,Yokoyama, Ryusuke,Nishitani, Kazuhiko,Ueda, Minoru. "Erratum: Protein ligand-tethered synthetic calcium indicator for localization control and spatiotemporal calcium imaging in plant cells (Bioorganic and Medicinal Chemistry Letters 26 (2016) (9-14) DOI: 10.1016/j.bmcl.2015.11.055)". . p. 2974 - 2974. Retrieved 2016.
• 2、 Caldwell, Stuart T.,Cairns, Andrew G.,Olson, Marnie,Chalmers, Susan,Sandison, Mairi,Mullen, William,McCarron, John G.,Hartley, Richard C.. "Synthesis of an azido-tagged low affinity ratiometric calcium sensor". . p. 9571 - 9578. Retrieved 2015.
• 3、 Csomos, Attila,Kontra, Bence,Jancsó, Attila,Galbács, Gábor,Deme, Ruth,Kele, Zoltán,Rózsa, Balázs József,Kovács, Ervin,Mucsi, Zoltán. "A Comprehensive Study of the Ca2+ Ion Binding of Fluorescently Labelled BAPTA Analogues". supporting information. p. 5248 - 5261. Retrieved 2021/10/19.
• 4、 -. "METHODS FOR PREPARING FUEL ADDITIVES". Page/Page column 34; 35. . Retrieved 2019/07/17.