2,2,2-Trifluoroethyl methacrylate

Base Information

• Chemical Name: 2,2,2-Trifluoroethyl methacrylate
• CAS No.: 54802-79-8
• Deprecated CAS: 918137-77-6,1212012-06-0
• Molecular Formula: C6H7F3O2
• Molecular Weight: 168.1137896
• European Community (EC) Number: 206-525-3,622-159-0
• NSC Number: 32617
• DSSTox Substance ID: DTXSID7059856
• Nikkaji Number: J107.718J
• Wikidata: Q72511125
• Mol file: 54802-79-8.mol

Synonyms:2,2,2-trifluoroethyl methacrylate;TFEMA

Chemical Property of 2,2,2-Trifluoroethyl methacrylate

Chemical Property:

• Melting Point: 50-52 °C(lit.)
• Refractive Index: n20/D 1.418(lit.)
• Solubility.: DMSO: soluble
• XLogP3: 2.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 3
• Exact Mass: 168.03981395
• Heavy Atom Count: 11
• Complexity: 171

Purity/Quality:

98%,99%, ^*data from raw suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=C)C(=O)OCC(F)(F)F

Technology Process of 2,2,2-Trifluoroethyl methacrylate

There total 3 articles about 2,2,2-Trifluoroethyl methacrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

2,2-dimethyl-propanol-1 (75-84-3) + chloroform (67-66-3,8013-54-5) + acetone (67-64-1) → C6H8ClF3O2 + 2,2,2-trifluoroethyl methacrylate (352-87-4,54802-79-8)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In benzonitrile; acetonitrile; at 50 ℃; for 42h;

DOI:10.1002/chem.201901933

Reference yield:

2,2,2-trifluoroethanol (75-89-8) + Methacryloyl chloride (920-46-7,26937-45-1) → 2,2,2-trifluoroethyl methacrylate (352-87-4,54802-79-8)

Guidance literature:

With 2,6-di-tert-butyl-4-methyl-phenol; triethylamine;

DOI:10.1016/j.jfluchem.2005.12.032

Reference yield:

poly(methacrylic acid) (79-41-4,25087-26-7,50867-57-7) + 2,2,2-trifluoroethanol (75-89-8) → 2,2,2-trifluoroethyl methacrylate (352-87-4,54802-79-8)

Guidance literature:

With sulfuric acid; hydroquinone; In benzene; Heating;

DOI:10.1016/S0022-1139(00)85059-9

upstream raw materials:

poly(methacrylic acid)

2,2,2-trifluoroethanol

Methacryloyl chloride

2,2-dimethyl-propanol-1