6609-57-0

Basic information

• Product Name: 2-Ethoxybenzonitrile
• Synonyms: 2-ETHOXYBENZONITRILE;O-ETHOXYBENZONITRILE;2-Ethoxybenzonitrile o-Ethoxybenzonitrile;2-ETHOXYBENZONITRILE 98%;O-ETHOXYBENZONITRILE 95%;Ethoxybenzonitril;Benzonitrile, 2-ethoxy-
• CAS NO: 6609-57-0
• Molecular Formula: C₉H₉NO
• Molecular Weight: 147.17
• Product Categories: Aromatic Nitriles;API intermediates;Miscellaneous;C8 to C9;Cyanides/Nitriles;Nitrogen Compounds;Building Blocks;C8 to C9;Chemical Synthesis;Nitrogen Compounds;Organic Building Blocks
• Mol File: 6609-57-0.mol
• Article Data: 19

Chemical Properties

• Melting Point: 5°C(lit.)
• Boiling Point: 154°C 20mm
• Flash Point: >230 °F
• Appearance: Clear colorless to pale yellow/Liquid
• Density: 1.053 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.0104mmHg at 25°C
• Refractive Index: n20/D 1.5322(lit.)
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 2-Ethoxybenzonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Ethoxybenzonitrile(6609-57-0)
• EPA Substance Registry System: 2-Ethoxybenzonitrile(6609-57-0)

Safety Data

• Hazard Codes: Xn,Xi
• Statements: 20/21/22-36/37/38
• Safety Statements: 26-37/39
• RIDADR: UN3276
• WGK Germany: 2
• HazardClass: 6.1
• PackingGroup: III
• Hazardous Substances Data: 6609-57-0(Hazardous Substances Data)

Usage

Uses

2-Ethoxybenzonitrile has been used in the synthesis of selective phosphodiesterase(V) inhibitor, vardenafil.

InChI:InChI=1/C9H9NO/c1-2-11-9-6-4-3-5-8(9)7-10/h3-6H,2H2,1H3

Upstream product

• 94-70-2 ortho-phenitidine 
• 938-73-8 2-ethoxybenzamide 
• 64-67-5 diethyl sulfate 
• 611-20-1 salicylonitrile 
• 873-32-5 2-Chlorobenzonitrile 
• 64-17-5 ethanol 
• 74-96-4 ethyl bromide 
• 403705-99-7 2-isopropoxybenzaldehyde O-methyloxime 
• 135-02-4 ortho-anisaldehyde 
• 22921-58-0 2-isopropoxybenzaldehyde 
• 90-02-8 salicylaldehyde 
• 107369-63-1 2-methoxybenzaldehyde O-methyloxime 
• 403705-98-6 2-ethoxybenzaldehyde O-methyloxime 
• 613-69-4 2-ethoxylbenzaldehyde 

Downstream Products

• 6609-59-2 2-butoxybenzonitrile 
• 611-20-1 salicylonitrile 
• 90921-35-0 2-isopropoxybenzonitrile 
• 6609-56-9 2-methoxy-benzonitrile 
• 98389-85-6 2-ethoxy-3,5-dinitro-benzonitrile 
• 109692-34-4 (E,E)-bis-(2-ethoxy-benzylidene)-hydrazine 
• 938-73-8 2-ethoxybenzamide 
• 134-11-2 2-ethoxybenzoic acid 
• 34825-99-5 2-(diphenylphosphanyl)benzonitrile 
• 923239-59-2 C₁₁H₁₁ClN₂O₂ 
• 74205-51-9 2-ethoxy benzylcyanide 
• 60906-78-7 1-chloromethyl-2-ethoxybenzene 
• 71672-75-8 2-ethoxybenzyl alcohol 

Relevant articles and documents

Aryl Ether Syntheses via Aromatic Substitution Proceeding under Mild Conditions

In this study, mild conditions for aromatic substitutions during the syntheses of aryl ethers were developed. In the reaction conditions, the choices of solvent, base, and the sequence for the addition of the reagents proved important. A wide variety of alcohols were used directly as nucleophiles and smoothly reacted with aryl chlorides that possessed either a nitro or a cyano group at either the ortho- or para-position. Controlled experiments we performed suggested that the reaction underwent a charge-transfer process mediated by a combination of DMF and tert-BuOK.

Oxadiazole o-phenoxy compound and application

The invention discloses an oxadiazole o-phenoxy compound. A structure is shown as a formula I: (The formula is shown in the description). The compound in the formula I has an excellent nematode-killing effect and can be used as a nematode-killing agent fo

Preparation method of alkoxy benzamide

The invention relates to a novel preparation method of alkoxy benzamide. Specifically, the method comprises steps as follows: chlorobenzonitrile is taken as a raw material and subjected to a reaction with alkaline substances in the presence of a catalyst, alkoxy benzoyl cyanide is generated and subjected to a hydrolysis reaction, and alkoxy benzamide is generated. The method has the advantages that the raw material is cheap and available, reaction conditions are mild, and postprocessing is convenient and simple.