3-Hydroxy-3,3-diphenylpropionic acid

Base Information

• Chemical Name: 3-Hydroxy-3,3-diphenylpropionic acid
• CAS No.: 3609-48-1
• Molecular Formula: C15H14O3
• Molecular Weight: 242.274
• Hs Code.: 2918199090
• Mol file: 3609-48-1.mol

Synonyms:3-hydroxy-3,3-diphenyl-propionic acid;3,3-diphenyl-3-hydroxypropanoic acid;3-Hydroxy-3,3-diphenyl-propionsaeure;3,3-diphenyl-3-hydroxypropionic acid;Benzenepropanoic acid, β-hydroxy-β-phenyl-;

Chemical Property of 3-Hydroxy-3,3-diphenylpropionic acid

Chemical Property:

• Vapor Pressure: 9.58E-08mmHg at 25°C
• Melting Point: 209-211oC
• Boiling Point: 418.3°Cat760mmHg
• Flash Point: 220.9°C
• PSA: 57.53000
• Density: 1.243g/cm³
• LogP: 2.39720

Purity/Quality:

99% ^*data from raw suppliers

3-HYDROXY-3,3-DIPHENYL-PROPIONIC ACID 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-Hydroxy-3,3-diphenylpropionic acid

There total 17 articles about 3-Hydroxy-3,3-diphenylpropionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 23.0%

1,1-Diphenylethylene (530-48-3) + carbon dioxide (124-38-9,18923-20-1) → 1,1-diphenylethanol (599-67-7) + 3,3-diphenylacrylic acid (606-84-8) + 3-hydroxy-3,3-diphenylpropanoic acid (3609-48-1)

Guidance literature:

With N,N,N',N'-tetramethylbenzidine; In acetonitrile; at 2 ℃; Further Variations:; Reagents; Temperatures; Product distribution; Quantum yield; UV-irradiation;

DOI:10.1016/j.tet.2007.02.013

Reference yield:

ethyl 3-hydroxy-3,3-diphenylpropanoate (894-18-8) → 3-hydroxy-3,3-diphenylpropanoic acid (3609-48-1)

Guidance literature:

With potassium hydroxide;

Reference yield:

benzophenone (119-61-9) + acetic acid (64-19-7,77671-22-8) → 3-hydroxy-3,3-diphenylpropanoic acid (3609-48-1)

Guidance literature:

With ammonia; lithium;

upstream raw materials:

1,1-diphenyl-3-buten-1-ol

ethyl 3-hydroxy-3,3-diphenylpropanoate

benzophenone

chloroacetic acid ethyl ester

Downstream raw materials:

3-hydroxy-3,3-diphenyl-propionic acid-(2-piperidino-ethyl ester)

1,1-diphenyl-1,3-propanediol

1-(3,3-diphenyl-3-hydroxypropanoyl)-4-(pyridin-3-ylcyanomethyl)piperazine

3-(2-Hydroxy-2,2-diphenylethyl)-1,4,2-dioxazol-5-on

Refernces

• 1、 Grajewska, Agnieszka,Oestreich, Martin. "Base-catalyzed dehydrogenative Si-o coupling of dihydrosilanes: Silylene protection of diols". supporting information; experimental part. p. 2482 - 2484. Retrieved 2010/11/18.
• 2、 -. "3,6-DISUBSTITUTED AZABICYCLO [3.1.0] HEXANE DERIVATIVES AS MUSCARINIC RECEPTOR ANTAGONISTS". Page/Page column 21-22. . Retrieved 2008/06/13.