β-Hydroxy-β-phenylbenzenepropionic acid ethyl ester

Base Information

• Chemical Name: β-Hydroxy-β-phenylbenzenepropionic acid ethyl ester
• CAS No.: 894-18-8
• Molecular Formula: C17H18O3
• Molecular Weight: 270.328
• Hs Code.: 2918199090
• Mol file: 894-18-8.mol

Synonyms:ethyl 3-hydroxy-3,3-diphenyl-propanoate;Benzenepropanoic acid, β-hydroxy-β-phenyl-, ethyl ester;ethyl 3,3-diphenyl-3-hydroxypropionate;Ethyl 3,3-diphenyl-3-hydroxypropanoate;

Chemical Property of β-Hydroxy-β-phenylbenzenepropionic acid ethyl ester

Chemical Property:

• Vapor Pressure: 3.89E-08mmHg at 25°C
• Boiling Point: 429.4°Cat760mmHg
• Flash Point: 178.5°C
• PSA: 46.53000
• Density: 1.142g/cm³
• LogP: 2.87570

Purity/Quality:

97% ^*data from raw suppliers

Ethyl3-hydroxy-3,3-diphenylpropanoate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of β-Hydroxy-β-phenylbenzenepropionic acid ethyl ester

There total 10 articles about β-Hydroxy-β-phenylbenzenepropionic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

benzophenone (119-61-9) + ethyl bromoacetate (105-36-2) → ethyl 3-hydroxy-3,3-diphenylpropanoate (894-18-8)

Guidance literature:

With ammonium chloride; zinc; for 0.0138889h; microwave irradiation;

Reference yield: 95.0%

benzophenone (119-61-9) + ethyl acetate (141-78-6) → ethyl 3-hydroxy-3,3-diphenylpropanoate (894-18-8)

Guidance literature:

ethyl acetate; With lithium diisopropyl amide; In hexane; at -78 ℃; for 0.5h;

benzophenone; In hexane; at -78 - 20 ℃; for 4h; Further stages.;

DOI:10.1039/b104130b

Reference yield: 77.0%

benzophenone (119-61-9) + chloroacetic acid ethyl ester (105-39-5) → ethyl 3-hydroxy-3,3-diphenylpropanoate (894-18-8)

Guidance literature:

With tris(2,2'-bipyridine)nickel(II) tetrafluoroborate; tetrabutylammomium bromide; zinc dibromide; In N,N-dimethyl-formamide; Ambient temperature; electrolysis (carbon fiber cathode, zinc rod anode);

DOI:10.1021/jo00006a012

upstream raw materials:

benzophenone

ethyl acetate

ethyl bromoacetate

ethanol

Downstream raw materials:

3-Hydroxy-3,3-diphenyl-propionsaeure-anilid

3-phenyl-1H-inden-1-one

N-benzyl-3-hydroxy-3,3-diphenylpropanamide

N-benzyl-3,3-diphenylprop-2-enamide