4-Bromo-2,3,5-trifluoropyridine

Base Information

• Chemical Name: 4-Bromo-2,3,5-trifluoropyridine
• CAS No.: 851178-96-6
• Molecular Formula: C₅HBrF₃N
• Molecular Weight: 211.969
• Hs Code.: 2933399990
• Mol file: 851178-96-6.mol

Synonyms:PC9693;QC-6964;

Chemical Property of 4-Bromo-2,3,5-trifluoropyridine

Chemical Property:

• Vapor Pressure: 3.43mmHg at 25°C
• Boiling Point: 158.2oC at 760 mmHg
• PKA: -1.44±0.10(Predicted)
• Flash Point: 49.5oC
• PSA: 12.89000
• Density: 1.901g/cm3
• LogP: 2.26140
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

4-Bromo-2,3,5-trifluoropyridine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Bromo-2,3,5-trifluoropyridine

There total 4 articles about 4-Bromo-2,3,5-trifluoropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

2,3,5‐trifluoropyridine (76469-41-5) → 4-bromo-2,3,5-trifluoropyridine (851178-96-6)

Guidance literature:

2,3,5‐trifluoropyridine; With n-butyllithium; In tetrahydrofuran; hexane; at -75 ℃; for 2h;

With bromine; at -75 ℃; for 1h;

DOI:10.1002/chem.200400837

Reference yield:

3,5,6-trifluoro-2-hydrazinopyridine (851179-05-0) → 4-bromo-2,3,5-trifluoropyridine (851178-96-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 65 percent / aq. CuSO₄ / Heating

2.1: BuLi / tetrahydrofuran; hexane / 2 h / -75 °C

2.2: 78 percent / Br₂ / 1 h / -75 °C

With n-butyllithium; copper(II) sulfate; In tetrahydrofuran; hexane;

DOI:10.1002/chem.200400837

Reference yield:

2,3,5,6-tetrafluoropyridine (2875-18-5) → 4-bromo-2,3,5-trifluoropyridine (851178-96-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 88 percent / hydrazine monohydrate / ethanol / 2 h / Heating

2.1: 65 percent / aq. CuSO₄ / Heating

3.1: BuLi / tetrahydrofuran; hexane / 2 h / -75 °C

3.2: 78 percent / Br₂ / 1 h / -75 °C

With n-butyllithium; hydrazine hydrate; copper(II) sulfate; In tetrahydrofuran; ethanol; hexane;

DOI:10.1002/chem.200400837

upstream raw materials:

2,3,5‐trifluoropyridine

3,5,6-trifluoro-2-hydrazinopyridine

2,3,5,6-tetrafluoropyridine

Pentafluoropyridine