3-METHOXYPHENOXYACETIC ACID

Base Information

• Chemical Name: 3-METHOXYPHENOXYACETIC ACID
• CAS No.: 2088-24-6
• Molecular Formula: C9H10 O4
• Molecular Weight: 182.176
• Hs Code.: 2918990090
• Mol file: 2088-24-6.mol

Synonyms:Aceticacid, (3-methoxyphenoxy)- (9CI); Acetic acid, (m-methoxyphenoxy)-(6CI,7CI,8CI); 2-(3-Methoxyphenoxy)acetic acid; 3-Methoxyphenoxyacetic acid;NSC 38177; m-Methoxyphenoxyacetic acid

Chemical Property of 3-METHOXYPHENOXYACETIC ACID

Chemical Property:

• Vapor Pressure: 9.11E-05mmHg at 25°C
• Melting Point: 116-117°C
• Boiling Point: 325.9°Cat760mmHg
• PKA: pK1:3.141 (25°C)
• Flash Point: 131.9°C
• PSA: 55.76000
• Density: 1.226g/cm³
• LogP: 1.15860
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

2-(3-Methoxyphenoxy)aceticAcid ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-22
• Safety Statements: 26-36

MSDS Files:

Useful:

Technology Process of 3-METHOXYPHENOXYACETIC ACID

There total 12 articles about 3-METHOXYPHENOXYACETIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

methyl (3-methoxyphenoxy)acetate (81720-20-9) → 3-methoxyphenoxyacetic acid (2088-24-6)

Guidance literature:

With iron(III) sulfate; water; In toluene; at 110 ℃; for 2h; Ionic liquid;

DOI:10.1039/c0nj00454e

Reference yield: 80.0%

O-methylresorcine (150-19-6) + sodium monochloroacetic acid (3926-62-3) → 3-methoxyphenoxyacetic acid (2088-24-6)

Guidance literature:

With sodium hydroxide; In water; at 60 ℃; for 7h;

DOI:10.1016/j.tet.2005.08.015

Reference yield: 70.0%

glycolic Acid (79-14-1) + 3-methoxy-1-iodobenzene (766-85-8) → 3-methoxyphenoxyacetic acid (2088-24-6)

Guidance literature:

With copper(l) iodide; caesium carbonate; In water; dimethyl sulfoxide; at 120 ℃; for 24h; Inert atmosphere; Schlenk technique;

DOI:10.1021/jo400702z

upstream raw materials:

(3-methoxy-phenoxy)-acetic acid ethyl ester

2-carboxymethoxy-4-methoxy-benzoic acid

sodium 4-methoxyphenolate

sodium monochloroacetic acid

Downstream raw materials:

(3-methoxy-phenoxy)-acetic acid ethyl ester

6-methoxy-benzofuran-3-ol

2-(3-methoxyphenoxy)acetyl chloride

2-(3-methoxyphenoxy)acetamide

Refernces

• 1、 Xin, Weixiang,Li, Zezhong,Wang, Qing,Du, Jin,Zhu, Mingyan,Zhou, Huchen. "Design and synthesis of α-phenoxy-N-sulfonylphenyl acetamides as Trypanosoma brucei Leucyl-tRNA synthetase inhibitors". . . Retrieved 2019/11/26.
• 2、 Lei, Kang,Li, Pan,Yang, Xue-Fang,Wang, Shi-Ben,Wang, Xue-Kun,Hua, Xue-Wen,Sun, Bin,Ji, Lu-Sha,Xu, Xiao-Hua. "Design and Synthesis of Novel 4-Hydroxyl-3-(2-phenoxyacetyl)-pyran-2-one Derivatives for Use as Herbicides and Evaluation of Their Mode of Action". . p. 10489 - 10497. Retrieved 2019/10/02.