2-chloro-N-(4-methyl-1,3-thiazol-2-yl)pyridine-3-carboxamide

Base Information

Chemical Name:2-chloro-N-(4-methyl-1,3-thiazol-2-yl)pyridine-3-carboxamide
CAS No.:85678-91-7
Molecular Formula:C₁₀H₈ClN₃OS
Molecular Weight:253.712
Hs Code.:
DSSTox Substance ID:DTXSID00356599
Wikidata:Q82136044
ChEMBL ID:CHEMBL1736035
Mol file:85678-91-7.mol

Synonyms:85678-91-7;2-chloro-N-(4-methyl-1,3-thiazol-2-yl)pyridine-3-carboxamide;2-chloro-N-(4-methyl-1,3-thiazol-2-yl)nicotinamide;AE-641/09636054;HMS2804F07;MLS001180348;CHEMBL1736035;DTXSID00356599;AKOS000161611;SMR000475893;EN300-10152414;Z30820183

Suppliers and Price of 2-chloro-N-(4-methyl-1,3-thiazol-2-yl)pyridine-3-carboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of 2-chloro-N-(4-methyl-1,3-thiazol-2-yl)pyridine-3-carboxamide

Chemical Property:

PSA：83.12000
LogP:2.82520
XLogP3:2.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:253.0076608
Heavy Atom Count:16
Complexity:266

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CSC(=N1)NC(=O)C2=C(N=CC=C2)Cl

Technology Process of 2-chloro-N-(4-methyl-1,3-thiazol-2-yl)pyridine-3-carboxamide

There total 2 articles about 2-chloro-N-(4-methyl-1,3-thiazol-2-yl)pyridine-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1603-91-4
4-methylthiazol-2-ylamine

: 49609-84-9
2-Chloronicotinoyl chloride

: 85678-91-7
2-Chloro-N-(4-methyl-thiazol-2-yl)-nicotinamide

Guidance literature:: With triethylamine; In benzene; for 3h; Heating;
DOI:10.1055/s-1983-30264

Reference yield:

: 2942-59-8
2-chloronicotinic acid

: 85678-91-7
2-Chloro-N-(4-methyl-thiazol-2-yl)-nicotinamide

Guidance literature:: Multi-step reaction with 2 steps

1: thionyl chloride / 3 h / Heating

2: 75 percent / triethylamine / benzene / 3 h / Heating

With thionyl chloride; triethylamine; In benzene;
DOI:10.1055/s-1983-30264