TOS-PEG5-THP

Base Information

• Chemical Name: TOS-PEG5-THP
• CAS No.: 86259-89-4
• Molecular Formula: C20H32O8S
• Molecular Weight: 432.535
• Mol file: 86259-89-4.mol

Synonyms:monotetrahydropyranyl tetraethylene glycol monotosylate;1-tosyl-13-(tetrahydropyran-2-yl)-1,4,7,10,13-pentaoxatridecane;1-(4-Toluenesulfonyl)-13-(tetrahydropyran-2-yl)-1,4,7,10,13-pentaoxatridecane;2-(1-tosyloxy-3,6,9-trioxaundecan-11-oxy)tetrahydropyran;1-tetrahydropyranyloxy-11-tosyloxy-3,6,9-trioxaundecane;Toluene-4-sulfonic acid 2-(2-{2-[2-(tetrahydro-pyran-2-yloxy)-ethoxy]-ethoxy}-ethoxy)-ethyl ester;1-tosyloxy-11-(tetrahydropyran-2-yloxy)-3,6,9-trioxaundecane;

Chemical Property of TOS-PEG5-THP

Chemical Property:

• PSA: 97.90000
• LogP: 3.37410

Purity/Quality:

99.3% ^*data from raw suppliers

Toluene-4-sulfonic acid 2-(2-{2-[2-(tetrahydropyran-2-yloxy)-ethoxy]-ethoxy}-ethoxy)-ethyl ester 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of TOS-PEG5-THP

There total 6 articles about TOS-PEG5-THP which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.3%

3,4-dihydro-2H-pyran (110-87-2) + p-toluenesulfonic acid 2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethyl ester (77544-60-6) → 2-(2-(2-(2-((tetrahydro-2H-pyran-2-yl)oxy)ethoxy)ethoxy)ethoxy)ethyl 4-methylbenzenesulfonate (86259-89-4)

Guidance literature:

With toluene-4-sulfonic acid; In tetrahydrofuran; at 20 ℃; for 36h; Inert atmosphere;

DOI:10.1016/j.tetlet.2014.04.066

Reference yield: 85.0%

2-(2-(2-(2-((tetrahydro-2H-pyran-2-yl)oxy)ethoxy)ethoxy)ethoxy)ethan-1-ol (128660-97-9) + p-toluenesulfonyl chloride (98-59-9) → 2-(2-(2-(2-((tetrahydro-2H-pyran-2-yl)oxy)ethoxy)ethoxy)ethoxy)ethyl 4-methylbenzenesulfonate (86259-89-4)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 22 ℃; for 24.25h;

Reference yield:

3,4-dihydro-2H-pyran (110-87-2) + Tetraethylene glycol (112-60-7) + p-toluenesulfonyl chloride (98-59-9) → O(CH2CH2O)4(CH(CH2)4O)2 + 2-(2-(2-(2-((tetrahydro-2H-pyran-2-yl)oxy)ethoxy)ethoxy)ethoxy)ethyl 4-methylbenzenesulfonate (86259-89-4)

Guidance literature:

3,4-dihydro-2H-pyran; Tetraethylene glycol; With toluene-4-sulfonic acid; In dichloromethane; at 20 ℃; for 24h; Inert atmosphere;

p-toluenesulfonyl chloride; With potassium hydroxide; In tetrahydrofuran; water; at 0 - 20 ℃; Overall yield = 285 g; Inert atmosphere;

DOI:10.1016/j.tetlet.2014.04.066

upstream raw materials:

3,4-dihydro-2H-pyran

p-toluenesulfonic acid 2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethyl ester

2-(2-(2-(2-((tetrahydro-2H-pyran-2-yl)oxy)ethoxy)ethoxy)ethoxy)ethan-1-ol

p-toluenesulfonyl chloride

Downstream raw materials:

2,5-Dimethyl-2-<2-<(12-tetrahydropyranyloxy)-1,4,7,10-tetraoxadodecanyl>phenyl>-3,4-dihydro-2H-pyrrole 1-Oxide

monotetrahydropyranyl octa(ethylene glycol) monobenzyl ether

1-phenyl-2,5,8,11,14,17,20,23-octaoxapenta-cosan-25-ol