1-(2,6-Dichloro-3-fluorophenyl)ethyl acetate

Base Information

Chemical Name:1-(2,6-Dichloro-3-fluorophenyl)ethyl acetate
CAS No.:877397-67-6
Molecular Formula:C10H9Cl2FO2
Molecular Weight:251.085
Hs Code.:
DSSTox Substance ID:DTXSID501189406
Nikkaji Number:J2.892.171C

Synonyms:1-(2,6-dichloro-3-fluorophenyl)ethyl acetate;877397-67-6;SCHEMBL1582077;IZHRGJAQMNPACR-UHFFFAOYSA-N;DTXSID501189406;1-(2,6-dichloro-3-fluorophenyl)ethylacetate;1-(2.6-dichloro-3-fluorophenyl)ethyl acetate;Benzenemethanol, 2,6-dichloro-3-fluoro-I+/--methyl-, 1-acetate

Suppliers and Price of 1-(2,6-Dichloro-3-fluorophenyl)ethyl acetate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of 1-(2,6-Dichloro-3-fluorophenyl)ethyl acetate

Chemical Property:

XLogP3:3.4
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:249.9963631
Heavy Atom Count:15
Complexity:238

Purity/Quality:: 95%-98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C1=C(C=CC(=C1Cl)F)Cl)OC(=O)C

Technology Process of 1-(2,6-Dichloro-3-fluorophenyl)ethyl acetate

There total 2 articles about 1-(2,6-Dichloro-3-fluorophenyl)ethyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 756520-66-8
1-(2,6-dichloro-3-fluorophenyl)ethanol

: 108-24-7
acetic anhydride

: 877397-67-6
1-(2,6-dichloro-3-fluorophenyl)ethyl acetate

Guidance literature:: With pyridine; at 23 ℃; for 12h; Large scale reaction;
DOI:10.1016/j.tetasy.2010.09.007

Reference yield:

: 290835-85-7
2',6'-dichloro-3'-fluoroacetophenone

: 877397-67-6
1-(2,6-dichloro-3-fluorophenyl)ethyl acetate

Guidance literature:: Multi-step reaction with 2 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 - 20 °C

2: pyridine / dichloromethane / 12 h / 20 °C

With pyridine; lithium aluminium tetrahydride; In tetrahydrofuran; dichloromethane;

Reference yield: 61.0%

: 877397-67-6
1-(2,6-dichloro-3-fluorophenyl)ethyl acetate

: 124-63-0
methanesulfonyl chloride

: 877397-68-7
(1S)-1-(2,6-dichloro-3-fluorophenyl)ethyl acetate

Guidance literature:: 1-(2,6-dichloro-3-fluorophenyl)ethyl acetate; With sodium hydroxide; In aq. phosphate buffer; at 20 ℃; for 20h; pH=7;

methanesulfonyl chloride; With pyridine; at 20 ℃; for 3h; Inert atmosphere;

With potassium acetate; In N,N-dimethyl-formamide; at 100 ℃; for 12h; Inert atmosphere;