(1S)-1-(2,6-dichloro-3-fluorophenyl)ethyl acetate

Base Information

Chemical Name:(1S)-1-(2,6-dichloro-3-fluorophenyl)ethyl acetate
CAS No.:877397-68-7
Molecular Formula:C₁₀H₉Cl₂FO₂
Molecular Weight:251.085
Hs Code.:
Mol file:877397-68-7.mol

Synonyms:(1S)-1-(2,6-dichloro-3-fluorophenyl)ethyl acetate

Suppliers and Price of (1S)-1-(2,6-dichloro-3-fluorophenyl)ethyl acetate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of (1S)-1-(2,6-dichloro-3-fluorophenyl)ethyl acetate

Chemical Property:

Purity/Quality:: 95%-98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of (1S)-1-(2,6-dichloro-3-fluorophenyl)ethyl acetate

There total 14 articles about (1S)-1-(2,6-dichloro-3-fluorophenyl)ethyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 877397-67-6
1-(2,6-dichloro-3-fluorophenyl)ethyl acetate

: 124-63-0
methanesulfonyl chloride

: 877397-68-7
(1S)-1-(2,6-dichloro-3-fluorophenyl)ethyl acetate

Guidance literature:: 1-(2,6-dichloro-3-fluorophenyl)ethyl acetate; With sodium hydroxide; In aq. phosphate buffer; at 20 ℃; for 20h; pH=7;

methanesulfonyl chloride; With pyridine; at 20 ℃; for 3h; Inert atmosphere;

With potassium acetate; In N,N-dimethyl-formamide; at 100 ℃; for 12h; Inert atmosphere;

Reference yield: 43.0%

: 877397-67-6
1-(2,6-dichloro-3-fluorophenyl)ethyl acetate

: 877397-68-7
(1S)-1-(2,6-dichloro-3-fluorophenyl)ethyl acetate

: 330156-50-8
(R)-1-(2,6-dichloro-3-fluorophenyl)ethan-1-ol

Guidance literature:: With pig liver esterase; sodium hydroxide; at 23 ℃; for 30h; optical yield given as %ee; enantioselective reaction; aq. phosphate buffer; Resolution of racemate; Large scale reaction; Enzymatic reaction;
DOI:10.1016/j.tetasy.2010.09.007

Reference yield:

: 877397-67-6
1-(2,6-dichloro-3-fluorophenyl)ethyl acetate

: 877397-68-7
(1S)-1-(2,6-dichloro-3-fluorophenyl)ethyl acetate

Guidance literature:: 1-(2,6-dichloro-3-fluorophenyl)ethyl acetate; With pig liver esterase; sodium hydroxide; at 23 ℃; for 30h; aq. phosphate buffer; Large scale reaction; Enzymatic reaction;

With pyridine; methanesulfonyl chloride; at 23 ℃; for 3h; Inert atmosphere;

With potassium acetate; In N,N-dimethyl-formamide; at 100 ℃; for 12h; optical yield given as %ee; enantioselective reaction; Inert atmosphere;
DOI:10.1016/j.tetasy.2010.09.007