3-[1-(2,6-Dichloro-3-fluorophenyl)ethoxy]-5-(1H-pyrazol-3-yl)-2-pyridinamine

Base Information

Chemical Name:3-[1-(2,6-Dichloro-3-fluorophenyl)ethoxy]-5-(1H-pyrazol-3-yl)-2-pyridinamine
CAS No.:877401-20-2
Molecular Formula:C₁₆H₁₃Cl₂FN₄O
Molecular Weight:367.21
Hs Code.:
ChEMBL ID:CHEMBL1824891
DSSTox Substance ID:DTXSID101140741

Synonyms:CHEMBL1824891;SCHEMBL1582214;DTXSID101140741;BDBM50352547;3-[1-(2,6-Dichloro-3-fluorophenyl)ethoxy]-5-(1H-pyrazol-3-yl)-2-pyridinamine;877401-20-2

Suppliers and Price of 3-[1-(2,6-Dichloro-3-fluorophenyl)ethoxy]-5-(1H-pyrazol-3-yl)-2-pyridinamine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-[1-(2,6-Dichloro-3-fluorophenyl)ethoxy]-5-(1H-pyrazol-3-yl)-2-pyridinamine

Chemical Property:

XLogP3:3.7
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:4
Exact Mass:366.0450446
Heavy Atom Count:24
Complexity:422

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(C1=C(C=CC(=C1Cl)F)Cl)OC2=C(N=CC(=C2)C3=CC=NN3)N

Technology Process of 3-[1-(2,6-Dichloro-3-fluorophenyl)ethoxy]-5-(1H-pyrazol-3-yl)-2-pyridinamine

There total 5 articles about 3-[1-(2,6-Dichloro-3-fluorophenyl)ethoxy]-5-(1H-pyrazol-3-yl)-2-pyridinamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 756520-48-6
5-iodo-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)pyridin-2-amine

: 844501-71-9
5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolane-2-yl)-1H-pyrazole

: 1331786-30-1,877401-20-2
3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1H-pyrazol-5-yl)pyridin-2-amine

Guidance literature:: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate; In 1,2-dimethoxyethane; water; at 80 ℃; for 12h; Inert atmosphere;
DOI:10.1021/jm2007613

Reference yield:

: 756520-66-8
1-(2,6-dichloro-3-fluorophenyl)ethanol

: 1331786-30-1,877401-20-2
3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1H-pyrazol-5-yl)pyridin-2-amine

Guidance literature:: Multi-step reaction with 4 steps

1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran; toluene / 4 h / 0 - 20 °C / Inert atmosphere

2: iron; acetic acid / ethanol / 1 h / Inert atmosphere; Reflux

3: N-iodo-succinimide / acetic acid; acetonitrile / 4 h / Inert atmosphere

4: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate / 1,2-dimethoxyethane; water / 12 h / 80 °C / Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; N-iodo-succinimide; iron; caesium carbonate; acetic acid; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; water; acetic acid; toluene; acetonitrile; 1: Mitsunobu reaction / 4: Suzuki coupling;
DOI:10.1021/jm2007613

Reference yield:

: 756521-08-1
(±)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-2-nitropyridine

: 1331786-30-1,877401-20-2
3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1H-pyrazol-5-yl)pyridin-2-amine

Guidance literature:: Multi-step reaction with 3 steps

1: iron; acetic acid / ethanol / 1 h / Inert atmosphere; Reflux

2: N-iodo-succinimide / acetic acid; acetonitrile / 4 h / Inert atmosphere

3: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate / 1,2-dimethoxyethane; water / 12 h / 80 °C / Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; N-iodo-succinimide; iron; caesium carbonate; acetic acid; In 1,2-dimethoxyethane; ethanol; water; acetic acid; acetonitrile; 3: Suzuki coupling;
DOI:10.1021/jm2007613