Technology Process of 1-Piperidinecarboxylic acid,
2-(2-methyl-2-propenyl)-3-(phenylmethoxy)-, phenylmethyl ester,
(2R,3S)-
There total 9 articles about 1-Piperidinecarboxylic acid,
2-(2-methyl-2-propenyl)-3-(phenylmethoxy)-, phenylmethyl ester,
(2R,3S)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium hydride;
In
N,N-dimethyl-formamide;
at 0 ℃;
for 4h;
DOI:10.3987/COM-05-S(T)12
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: LiBEt3H / tetrahydrofuran / 0.5 h / -78 °C
2.1: NaH / tetrahydrofuran
2.2: 232 mg / tetrahydrofuran / 20 °C
3.1: 88 percent / tetrahydrofuran / 0.5 h / 0 °C
4.1: 81 percent / tetrahydrofuran / 2.5 h / -40 - 20 °C
5.1: ZnBr2 / CH2Cl2 / 20 °C
6.1: 678 mg / SmI2; HMPA / tetrahydrofuran; methanol / 0 - 20 °C
7.1: LiAlH4 / tetrahydrofuran / 3 h / 65 °C
8.1: 195 mg / TEA; DMAP / CH2Cl2 / 20 °C
9.1: 90 percent / NaH / dimethylformamide / 4 h / 0 °C
With
N,N,N,N,N,N-hexamethylphosphoric triamide; dmap; lithium aluminium tetrahydride; samarium diiodide; TEA; sodium hydride; lithium triethylborohydride; zinc dibromide;
In
tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
2.2: Horner-Emmons-Michael reaction;
DOI:10.3987/COM-05-S(T)12
- Guidance literature:
-
Multi-step reaction with 3 steps
1: LiAlH4 / tetrahydrofuran / 3 h / 65 °C
2: 195 mg / TEA; DMAP / CH2Cl2 / 20 °C
3: 90 percent / NaH / dimethylformamide / 4 h / 0 °C
With
dmap; lithium aluminium tetrahydride; TEA; sodium hydride;
In
tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.3987/COM-05-S(T)12
