2-Phenyl-4-[(E)-1-phenylethylidene]oxazol-5(4H)-one

Base Information

• Chemical Name: 2-Phenyl-4-[(E)-1-phenylethylidene]oxazol-5(4H)-one
• CAS No.: 57427-91-5
• Molecular Formula: C17H13NO2
• Molecular Weight: 263.296
• NSC Number: 351965
• DSSTox Substance ID: DTXSID10419563
• Nikkaji Number: J340.571K
• Wikidata: Q82230617
• ChEMBL ID: CHEMBL1988434
• Mol file: 57427-91-5.mol

Synonyms:57427-91-5;AC1NTNKE;SCHEMBL7581232;CHEMBL1988434;DTXSID10419563;NSC351965;NSC-351965;2-Phenyl-4-[(E)-1-phenylethylidene]oxazol-5(4H)-one

Chemical Property of 2-Phenyl-4-[(E)-1-phenylethylidene]oxazol-5(4H)-one

Chemical Property:

• Vapor Pressure: 2.04E-06mmHg at 25°C
• Boiling Point: 394°Cat760mmHg
• Flash Point: 172.3°C
• Density: 1.15g/cm³
• XLogP3: 4.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 263.094628657
• Heavy Atom Count: 20
• Complexity: 438

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=C1C(=O)OC(=N1)C2=CC=CC=C2)C3=CC=CC=C3
• Isomeric SMILES: C/C(=C\1/C(=O)OC(=N1)C2=CC=CC=C2)/C3=CC=CC=C3

Technology Process of 2-Phenyl-4-[(E)-1-phenylethylidene]oxazol-5(4H)-one

There total 9 articles about 2-Phenyl-4-[(E)-1-phenylethylidene]oxazol-5(4H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

(Z)-2-phenyl-4-(α-phenylethylidene)-5-(4H)-oxazolone (69015-75-4) → (E)-2-phenyl-4-(α-phenylethylidene)-5-(4H)-oxazolone (57427-91-5)

Guidance literature:

With hydrogen bromide; dibenzoyl peroxide; In toluene; cooling;

DOI:10.1016/j.tet.2003.11.044

Reference yield: 46.0%

Hippuric Acid (495-69-2,140480-84-8,21251-67-2,91787-63-2,66407-11-2) + acetophenone (98-86-2) → (E)-2-phenyl-4-(α-phenylethylidene)-5-(4H)-oxazolone (57427-91-5) + (Z)-2-phenyl-4-(α-phenylethylidene)-5-(4H)-oxazolone (69015-75-4)

Guidance literature:

With lead(IV) tetraacetate; acetic anhydride; In tetrahydrofuran; for 24h; Heating;

Reference yield: 17.0%

diazomethane (186581-53-3,908094-01-9,334-88-3) + (E)-2-phenyl-4-benzylidene-5(4H)-oxazolone (15732-43-1,5839-91-8) → (E)-2-phenyl-4-(α-phenylethylidene)-5-(4H)-oxazolone (57427-91-5) + (E)-(1,5-diphenyl)-7-oxo-6-oxa-4-azaspiro<2.4>hept-4-ene (4525-04-6,64283-23-4,64283-24-5,66108-19-8,66108-20-1) + (Z)-(1,5-diphenyl)-7-oxo-6-oxa-4-azaspiro<2.4>hept-4-ene (4525-04-6,64283-23-4,64283-24-5,66108-19-8,66108-20-1)

Guidance literature:

In tetrahydrofuran; diethyl ether;

upstream raw materials:

(Z)-2-phenyl-4-(α-phenylethylidene)-5-(4H)-oxazolone

Hippuric Acid

acetophenone

diazomethane

Downstream raw materials:

N-((E)-1-Cyclohexylcarbamoyl-2-phenyl-propenyl)-benzamide

N-[(E)-1-(4-Methoxy-phenylcarbamoyl)-2-phenyl-propenyl]-benzamide

anilide of 1-phenyl-4-methyl-3-isoquinolincarboxylic acid

(Z)-2,3-diphenyl-5-(α-phenylethylidene)-4(5H)-imidazolone