PEG9-Tos

Base Information

Chemical Name:PEG9-Tos
CAS No.:886469-23-4
Molecular Formula:C23H40O11S
Molecular Weight:524.63
Hs Code.:2942000090
Mol file:886469-23-4.mol

Synonyms:3,6,9,12,15,18,21-Heptaoxatricosane-1,23-diol, 1-(4-methylbenzenesulfonate);3,6,9,12,15,18,21-Heptaoxatricosane-1,23-diol, mono(4-methylbenzenesulfonate) (9CI);23-Hydroxy-3,6,9,12,15,18,21-heptaoxatricosyl 4-methylbenzenesulfonate;Octa(ethylene glycol) mono tosylate;

Suppliers and Price of PEG9-Tos

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

BroadPharm
PEG9-Tos 98%
250 MG
$ 350.00

BroadPharm
PEG9-Tos 98%
500 MG
$ 540.00

Apolloscientific
PEG9-Tos
250mg
$ 681.00

Activate Scientific
Tos-PEG8-OH 95+%
1 g
$ 532.00

Acrotein
Tos-PEG8-OH 97%
0.5g
$ 275.00

Absolute Chiral
23-hydroxy-3,6,9,12,15,18,21-heptaoxatricosyl4-methylbenzenesulfonate 95%
100 mg
$ 198.00

Total 13 raw suppliers

Chemical Property of PEG9-Tos

Chemical Property:

PSA：136.59000
LogP:1.88960
Solubility.:Soluble in Water, DMSO, DCM, DMF

Purity/Quality:

97% ^*data from raw suppliers

PEG9-Tos 98% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Description PEG9-Tos is a PEG linker containing a hydroxyl group with a tosyl group. The hydrophilic PEG spacer increases solubility in aqueous media. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The tosyl group is a very good leaving group for nucleophilic substitution reactions.

Technology Process of PEG9-Tos

There total 3 articles about PEG9-Tos which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 5117-19-1
octaethylene glycol

: 98-59-9
p-toluenesulfonyl chloride

: 886469-23-4
2-(2-{2-[2-(2-{2-[2-(2-hydroxyethoxy)ethoxy]ethoxy}ethoxy)ethoxy]ethoxy}ethoxy)ethyl 4-methylbenzenesulfonate

Guidance literature:: With silver(l) oxide; In dichloromethane; at 0 ℃; for 0.25h;
DOI:10.1016/j.tetlet.2011.03.144

Reference yield: 54.0%

: 886469-23-4
2-(2-{2-[2-(2-{2-[2-(2-hydroxyethoxy)ethoxy]ethoxy}ethoxy)ethoxy]ethoxy}ethoxy)ethyl 4-methylbenzenesulfonate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 25 ℃;

Reference yield:

: 112-60-7
Tetraethylene glycol

: 886469-23-4
2-(2-{2-[2-(2-{2-[2-(2-hydroxyethoxy)ethoxy]ethoxy}ethoxy)ethoxy]ethoxy}ethoxy)ethyl 4-methylbenzenesulfonate

Guidance literature:: Multi-step reaction with 2 steps

1.1: N-ethyl-N,N-diisopropylamine; dmap; thionyl chloride / 0 °C

1.2: 0 °C

2.1: potassium iodide; silver(l) oxide / dichloromethane; water / 8 h / 0 - 5 °C

With dmap; thionyl chloride; N-ethyl-N,N-diisopropylamine; potassium iodide; silver(l) oxide; In dichloromethane; water;