Methyl 4,5-dichlorothiophene-2-carboxylate

Base Information

• Chemical Name: Methyl 4,5-dichlorothiophene-2-carboxylate
• CAS No.: 89281-29-8
• Molecular Formula: C6H4Cl2O2S
• Molecular Weight: 211.06600
• Mol file: 89281-29-8.mol

Synonyms:2,3-dichlorothiophene-5-carboxylic acid methyl ester;4,5-Dichlor-thiophen-2-carbonsaeuremethylester;4,5-dichloro-thiophene-2-carboxylic acid methyl ester;2.3-Dichlor-thiophen-5-carbonsaeure-methylester;

Chemical Property of Methyl 4,5-dichlorothiophene-2-carboxylate

Chemical Property:

• Boiling Point: 281.3±35.0 °C(Predicted)
• PSA: 54.54000
• Density: 1.500±0.06 g/cm3(Predicted)
• LogP: 2.84150
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

97% ^*data from raw suppliers

Methyl4,5-dichlorothiophene-2-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Methyl 4,5-dichlorothiophene-2-carboxylate is used as a reactant in the preparation of 2-aryl indole neurokinin NK receptor antagonists in relation to optimization of amide substituent.

Technology Process of Methyl 4,5-dichlorothiophene-2-carboxylate

There total 5 articles about Methyl 4,5-dichlorothiophene-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

methanol (67-56-1) + 4,5-dichlorothiophene-2-carboxylic acid (31166-29-7) → 2,3-dichlorothiophene-5-carboxylic acid methyl ester (89281-29-8)

Guidance literature:

With sulfuric acid; for 18h; Heating;

DOI:10.1007/BF00809650

Reference yield:

thiophene-2-carboxylic acid methyl ester (5380-42-7) → 2,3-dichlorothiophene-5-carboxylic acid methyl ester (89281-29-8)

Guidance literature:

With N-chloro-succinimide; sulfuric acid; trifluoroacetic acid; at 0 ℃; for 0.166667h; Time;

DOI:10.3184/174751914X14116517685637

Reference yield:

C5HCl2O2S(1-) + methyl iodide (74-88-4) → 2,3-dichlorothiophene-5-carboxylic acid methyl ester (89281-29-8)

Guidance literature:

In N,N-dimethyl-formamide; at 90 ℃; for 2h;

DOI:10.1021/acs.organomet.1c00372

upstream raw materials:

methanol

4,5-dichlorothiophene-2-carboxylic acid

2-thiophenylcarboxylic acid

thiophene-2-carboxylic acid methyl ester

Downstream raw materials:

4,5-dichlorothiophene-2-carboxylic acid

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 89281-29-8 Methyl 4,5-dichlorothiophene-2-carboxylate

Send

Send

Metric Ton KG G Pound L ML

Send

Send