Carbamic acid, [4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan -4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-, phenyl ester, cis-

Base Information

Chemical Name:Carbamic acid, [4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan -4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-, phenyl ester, cis-
CAS No.:89848-10-2
Molecular Formula:C37H35Cl2N5O5
Molecular Weight:700.621
Hs Code.:

Carbamic acid,
[4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan
-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-, phenyl ester, cis-

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Chemical Property of Carbamic acid, [4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan -4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-, phenyl ester, cis-

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Technology Process of Carbamic acid, [4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan -4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-, phenyl ester, cis-

There total 6 articles about Carbamic acid, [4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan -4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-, phenyl ester, cis- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 89848-08-8
4-(4-{4-[(2R,4S)-2-(2,4-Dichloro-phenyl)-2-imidazol-1-ylmethyl-[1,3]dioxolan-4-ylmethoxy]-phenyl}-piperazin-1-yl)-phenylamine

: 1885-14-9
phenyl chloroformate

: 89848-10-2
[4-(4-{4-[(2R,4S)-2-(2,4-Dichloro-phenyl)-2-imidazol-1-ylmethyl-[1,3]dioxolan-4-ylmethoxy]-phenyl}-piperazin-1-yl)-phenyl]-carbamic acid phenyl ester

Guidance literature:: With pyridine; In chloroform; for 3h;
DOI:10.1021/jm00373a015

Reference yield:

: 61397-61-3
cis-[2-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-yl)methyl-(1,3-dioxolan-4-yl)]methyl methanesulfonate

: 89848-10-2
[4-(4-{4-[(2R,4S)-2-(2,4-Dichloro-phenyl)-2-imidazol-1-ylmethyl-[1,3]dioxolan-4-ylmethoxy]-phenyl}-piperazin-1-yl)-phenyl]-carbamic acid phenyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) NaH / 1.) Me₂SO, 1 h, 2.) Me₂SO, 80 deg C, 5 h

2: 71 percent / NaOH / butan-1-ol / Heating

3: 54 percent / K₂CO₃ / dimethylsulfoxide / 120 °C

4: 97 percent / H₂, thiophene / 5percent Pd/C / 2-methoxy-ethanol; methanol / 50 °C / Heating

5: 82 percent / pyridine / CHCl₃ / 3 h

With thiophene; pyridine; sodium hydroxide; hydrogen; sodium hydride; potassium carbonate; palladium on activated charcoal; In methanol; chloroform; 2-methoxy-ethanol; dimethyl sulfoxide; butan-1-ol;
DOI:10.1021/jm00373a015

Reference yield:

: 65277-42-1
ketoconazole

: 89848-10-2
[4-(4-{4-[(2R,4S)-2-(2,4-Dichloro-phenyl)-2-imidazol-1-ylmethyl-[1,3]dioxolan-4-ylmethoxy]-phenyl}-piperazin-1-yl)-phenyl]-carbamic acid phenyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 71 percent / NaOH / butan-1-ol / Heating

2: 54 percent / K₂CO₃ / dimethylsulfoxide / 120 °C

3: 97 percent / H₂, thiophene / 5percent Pd/C / 2-methoxy-ethanol; methanol / 50 °C / Heating

4: 82 percent / pyridine / CHCl₃ / 3 h

With thiophene; pyridine; sodium hydroxide; hydrogen; potassium carbonate; palladium on activated charcoal; In methanol; chloroform; 2-methoxy-ethanol; dimethyl sulfoxide; butan-1-ol;
DOI:10.1021/jm00373a015